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Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain.
Muratspahić E, Tomašević N, Koehbach J, Duerrauer L, Hadžić S, Castro J, Schober G, Sideromenos S, Clark RJ, Brierley SM, Craik DJ, Gruber CW. Muratspahić E, et al. Among authors: schober g. J Med Chem. 2021 Jul 8;64(13):9042-9055. doi: 10.1021/acs.jmedchem.1c00158. Epub 2021 Jun 23. J Med Chem. 2021. PMID: 34162205 Free PMC article.
Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity.
Castro J, Harrington AM, Lieu T, Garcia-Caraballo S, Maddern J, Schober G, O'Donnell T, Grundy L, Lumsden AL, Miller P, Ghetti A, Steinhoff MS, Poole DP, Dong X, Chang L, Bunnett NW, Brierley SM. Castro J, et al. Among authors: schober g. JCI Insight. 2019 Oct 17;4(20):e131712. doi: 10.1172/jci.insight.131712. JCI Insight. 2019. PMID: 31536477 Free PMC article.
Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents.
Castro J, Garcia-Caraballo S, Maddern J, Schober G, Lumsden A, Harrington A, Schmiel S, Lindstrom B, Adams J, Brierley SM. Castro J, et al. Among authors: schober g. Pain. 2022 Jan 1;163(1):e72-e86. doi: 10.1097/j.pain.0000000000002314. Pain. 2022. PMID: 33863856 Free PMC article.
Pharmacological Inhibition of the Voltage-Gated Sodium Channel NaV1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome.
Jiang Y, Castro J, Blomster LV, Agwa AJ, Maddern J, Schober G, Herzig V, Chow CY, Cardoso FC, Demétrio De Souza França P, Gonzales J, Schroeder CI, Esche S, Reiner T, Brierley SM, King GF. Jiang Y, et al. Among authors: schober g. ACS Pharmacol Transl Sci. 2021 Jun 7;4(4):1362-1378. doi: 10.1021/acsptsci.1c00072. eCollection 2021 Aug 13. ACS Pharmacol Transl Sci. 2021. PMID: 34423271 Free PMC article.
Gut enterochromaffin cells drive visceral pain and anxiety.
Bayrer JR, Castro J, Venkataraman A, Touhara KK, Rossen ND, Morrie RD, Maddern J, Hendry A, Braverman KN, Garcia-Caraballo S, Schober G, Brizuela M, Castro Navarro FM, Bueno-Silva C, Ingraham HA, Brierley SM, Julius D. Bayrer JR, et al. Among authors: schober g. Nature. 2023 Apr;616(7955):137-142. doi: 10.1038/s41586-023-05829-8. Epub 2023 Mar 22. Nature. 2023. PMID: 36949192 Free PMC article.
Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass.
Lumsden AL, Martin AM, Sun EW, Schober G, Isaacs NJ, Pezos N, Wattchow DA, de Fontgalland D, Rabbitt P, Hollington P, Sposato L, Due SL, Rayner CK, Nguyen NQ, Liou AP, Jackson VM, Young RL, Keating DJ. Lumsden AL, et al. Among authors: schober g. Nutrients. 2019 Jan 22;11(2):234. doi: 10.3390/nu11020234. Nutrients. 2019. PMID: 30678223 Free PMC article.
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