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Rapid generation of potent antibodies by autonomous hypermutation in yeast.
Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Wellner A, et al. Nat Chem Biol. 2021 Oct;17(10):1057-1064. doi: 10.1038/s41589-021-00832-4. Epub 2021 Jun 24. Nat Chem Biol. 2021. PMID: 34168368 Free PMC article.
Rapid generation of potent antibodies by autonomous hypermutation in yeast.
Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Wellner A, et al. bioRxiv [Preprint]. 2020 Nov 11:2020.11.11.378778. doi: 10.1101/2020.11.11.378778. bioRxiv. 2020. Update in: Nat Chem Biol. 2021 Oct;17(10):1057-1064. doi: 10.1038/s41589-021-00832-4 PMID: 33200136 Free PMC article. Updated. Preprint.
Simple yet functional phosphate-loop proteins.
Romero Romero ML, Yang F, Lin YR, Toth-Petroczy A, Berezovsky IN, Goncearenco A, Yang W, Wellner A, Kumar-Deshmukh F, Sharon M, Baker D, Varani G, Tawfik DS. Romero Romero ML, et al. Among authors: wellner a. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11943-E11950. doi: 10.1073/pnas.1812400115. Epub 2018 Nov 30. Proc Natl Acad Sci U S A. 2018. PMID: 30504143 Free PMC article.
Discovery of VH domains that allosterically inhibit ENPP1.
Solomon PE, Bracken CJ, Carozza JA, Wang H, Young EP, Wellner A, Liu CC, Sweet-Cordero EA, Li L, Wells JA. Solomon PE, et al. Among authors: wellner a. Nat Chem Biol. 2024 Jan;20(1):30-41. doi: 10.1038/s41589-023-01368-5. Epub 2023 Jul 3. Nat Chem Biol. 2024. PMID: 37400538 Free PMC article.
An in silico method to assess antibody fragment polyreactivity.
Harvey EP, Shin JE, Skiba MA, Nemeth GR, Hurley JD, Wellner A, Shaw AY, Miranda VG, Min JK, Liu CC, Marks DS, Kruse AC. Harvey EP, et al. Among authors: wellner a. Nat Commun. 2022 Dec 7;13(1):7554. doi: 10.1038/s41467-022-35276-4. Nat Commun. 2022. PMID: 36477674 Free PMC article.
Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and Haemophilus infection in COPD.
Winslow S, Odqvist L, Diver S, Riise R, Abdillahi S, Wingren C, Lindmark H, Wellner A, Lundin S, Yrlid L, Ax E, Djukanovic R, Sridhar S, Higham A, Singh D, Southworth T, Brightling CE, Olsson HK, Jevnikar Z. Winslow S, et al. Among authors: wellner a. Eur Respir J. 2021 Oct 14;58(4):2003312. doi: 10.1183/13993003.03312-2020. Print 2021 Oct. Eur Respir J. 2021. PMID: 33766947 Free article.
44 results