Parrott N - Search Results

1

Characterization of Hepatic UDP-Glucuronosyltransferase Enzyme Abundance-Activity Correlations and Population Variability Using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes.

Takahashi RH, Forrest WF, Smith AD, Badee J, Qiu N, Schmidt S, Collier AC, Parrott N, Fowler S. Takahashi RH, et al. Among authors: parrott n. Drug Metab Dispos. 2021 Sep;49(9):760-769. doi: 10.1124/dmd.121.000474. Epub 2021 Jun 29. Drug Metab Dispos. 2021. PMID: 34187837

2

Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog.

Heikkinen AT, Friedlein A, Lamerz J, Jakob P, Cutler P, Fowler S, Williamson T, Tolando R, Lave T, Parrott N. Heikkinen AT, et al. Among authors: parrott n. Pharm Res. 2012 Jul;29(7):1832-42. doi: 10.1007/s11095-012-0707-7. Epub 2012 Feb 22. Pharm Res. 2012. PMID: 22354837

3

Expression profiles of metabolic enzymes and drug transporters in the liver and along the intestine of beagle dogs.

Haller S, Schuler F, Lazic SE, Bachir-Cherif D, Krämer SD, Parrott NJ, Steiner G, Belli S. Haller S, et al. Drug Metab Dispos. 2012 Aug;40(8):1603-10. doi: 10.1124/dmd.112.045443. Epub 2012 May 17. Drug Metab Dispos. 2012. PMID: 22596220

4

In vitro to in vivo extrapolation and physiologically based modeling of cytochrome P450 mediated metabolism in beagle dog gut wall and liver.

Heikkinen AT, Fowler S, Gray L, Li J, Peng Y, Yadava P, Railkar A, Parrott N. Heikkinen AT, et al. Among authors: parrott n. Mol Pharm. 2013 Apr 1;10(4):1388-99. doi: 10.1021/mp300692k. Epub 2013 Mar 13. Mol Pharm. 2013. PMID: 23438212

5

Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions.

Boetsch C, Parrott N, Fowler S, Poirier A, Hainzl D, Banken L, Martin-Facklam M, Hofmann C. Boetsch C, et al. Among authors: parrott n. Clin Pharmacokinet. 2016 Feb;55(2):237-47. doi: 10.1007/s40262-015-0312-0. Clin Pharmacokinet. 2016. PMID: 26341813 Clinical Trial.

6

Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non-Michaelis-Menten P450 Kinetics on Fraction Metabolized.

Fowler S, Guerini E, Qiu N, Cleary Y, Parrott N, Greig G, Mallalieu NL. Fowler S, et al. Among authors: parrott n. J Pharmacol Exp Ther. 2017 Jan;360(1):164-173. doi: 10.1124/jpet.116.237214. Epub 2016 Nov 7. J Pharmacol Exp Ther. 2017. PMID: 27821711 Clinical Trial.

7

Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.

Kratochwil NA, Meille C, Fowler S, Klammers F, Ekiciler A, Molitor B, Simon S, Walter I, McGinnis C, Walther J, Leonard B, Triyatni M, Javanbakht H, Funk C, Schuler F, Lavé T, Parrott NJ. Kratochwil NA, et al. AAPS J. 2017 Mar;19(2):534-550. doi: 10.1208/s12248-016-0019-7. Epub 2017 Jan 3. AAPS J. 2017. PMID: 28050713 Free article.

8

Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities.

Fowler S, Morcos PN, Cleary Y, Martin-Facklam M, Parrott N, Gertz M, Yu L. Fowler S, et al. Among authors: parrott n. Curr Pharmacol Rep. 2017;3(1):36-49. doi: 10.1007/s40495-017-0082-5. Epub 2017 Feb 1. Curr Pharmacol Rep. 2017. PMID: 28261547 Free PMC article. Review.

9

Model-Based Assessments of CYP-Mediated Drug-Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development.

Cleary Y, Gertz M, Morcos PN, Yu L, Youdim K, Phipps A, Fowler S, Parrott N. Cleary Y, et al. Among authors: parrott n. Clin Pharmacol Ther. 2018 Sep;104(3):505-514. doi: 10.1002/cpt.956. Epub 2017 Dec 27. Clin Pharmacol Ther. 2018. PMID: 29226313

10

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.

Kratochwil NA, Triyatni M, Mueller MB, Klammers F, Leonard B, Turley D, Schmaler J, Ekiciler A, Molitor B, Walter I, Gonsard PA, Tournillac CA, Durrwell A, Marschmann M, Jones R, Ullah M, Boess F, Ottaviani G, Jin Y, Parrott NJ, Fowler S. Kratochwil NA, et al. J Pharmacol Exp Ther. 2018 May;365(2):237-248. doi: 10.1124/jpet.117.245712. Epub 2018 Feb 16. J Pharmacol Exp Ther. 2018. PMID: 29453199

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

203 results

Search Page

Filters