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Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.
Zhang M, Aguilar A, Xu S, Huang L, Chinnaswamy K, Sleger T, Wang B, Gross S, Nicolay BN, Ronseaux S, Harvey K, Wang Y, McEachern D, Kirchhoff PD, Liu Z, Stuckey J, Tron AE, Liu T, Wang S. Zhang M, et al. Among authors: liu z, liu t. J Med Chem. 2021 Jul 22;64(14):10333-10349. doi: 10.1021/acs.jmedchem.1c00789. Epub 2021 Jul 1. J Med Chem. 2021. PMID: 34196551 Free PMC article.
Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein.
Zhou H, Bai L, Xu R, Zhao Y, Chen J, McEachern D, Chinnaswamy K, Wen B, Dai L, Kumar P, Yang CY, Liu Z, Wang M, Liu L, Meagher JL, Yi H, Sun D, Stuckey JA, Wang S. Zhou H, et al. Among authors: liu z, liu l. J Med Chem. 2019 Dec 26;62(24):11280-11300. doi: 10.1021/acs.jmedchem.9b01530. Epub 2019 Dec 10. J Med Chem. 2019. PMID: 31747516 Free PMC article.
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