Pantsar T - Search Results

1

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors.

Andreev S, Pantsar T, Tesch R, Kahlke N, El-Gokha A, Ansideri F, Grätz L, Romasco J, Sita G, Geibel C, Lämmerhofer M, Tarozzi A, Knapp S, Laufer SA, Koch P. Andreev S, et al. Among authors: pantsar t. J Med Chem. 2022 Jan 27;65(2):1283-1301. doi: 10.1021/acs.jmedchem.0c02146. Epub 2021 Jul 2. J Med Chem. 2022. PMID: 34213342

2

Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors.

Heider F, Ansideri F, Tesch R, Pantsar T, Haun U, Döring E, Kudolo M, Poso A, Albrecht W, Laufer SA, Koch P. Heider F, et al. Among authors: pantsar t. Eur J Med Chem. 2019 Aug 1;175:309-329. doi: 10.1016/j.ejmech.2019.04.035. Epub 2019 Apr 24. Eur J Med Chem. 2019. PMID: 31096153

3

Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3β Inhibitors.

Andreev S, Pantsar T, Ansideri F, Kudolo M, Forster M, Schollmeyer D, Laufer SA, Koch P. Andreev S, et al. Among authors: pantsar t. Molecules. 2019 Jun 25;24(12):2331. doi: 10.3390/molecules24122331. Molecules. 2019. PMID: 31242571 Free PMC article.

4

Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks.

Heider F, Pantsar T, Kudolo M, Ansideri F, De Simone A, Pruccoli L, Schneider T, Goettert MI, Tarozzi A, Andrisano V, Laufer SA, Koch P. Heider F, et al. Among authors: pantsar t. ACS Med Chem Lett. 2019 Aug 26;10(10):1407-1414. doi: 10.1021/acsmedchemlett.9b00177. eCollection 2019 Oct 10. ACS Med Chem Lett. 2019. PMID: 31620226 Free PMC article.

5

Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.

Pedreira JGB, Nahidino P, Kudolo M, Pantsar T, Berger BT, Forster M, Knapp S, Laufer S, Barreiro EJ. Pedreira JGB, et al. Among authors: pantsar t. J Med Chem. 2020 Jul 9;63(13):7347-7354. doi: 10.1021/acs.jmedchem.0c00508. Epub 2020 Jun 11. J Med Chem. 2020. PMID: 32462866

6

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4.

Kircher T, Pantsar T, Oder A, Peter von Kries J, Juchum M, Pfaffenrot B, Kloevekorn P, Albrecht W, Selig R, Laufer S. Kircher T, et al. Among authors: pantsar t. Eur J Med Chem. 2021 Jan 1;209:112901. doi: 10.1016/j.ejmech.2020.112901. Epub 2020 Oct 4. Eur J Med Chem. 2021. PMID: 33092905

7

Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability.

Andreev S, Pantsar T, El-Gokha A, Ansideri F, Kudolo M, Anton DB, Sita G, Romasco J, Geibel C, Lämmerhofer M, Goettert MI, Tarozzi A, Laufer SA, Koch P. Andreev S, et al. Among authors: pantsar t. Int J Mol Sci. 2020 Oct 22;21(21):7823. doi: 10.3390/ijms21217823. Int J Mol Sci. 2020. PMID: 33105671 Free PMC article.

8

Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors.

Pantsar T, Kaiser PD, Kudolo M, Forster M, Rothbauer U, Laufer SA. Pantsar T, et al. Nat Commun. 2022 Jan 28;13(1):569. doi: 10.1038/s41467-022-28164-4. Nat Commun. 2022. PMID: 35091547 Free PMC article.

9

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library.

Mustonen EK, Pantsar T, Rashidian A, Reiner J, Schwab M, Laufer S, Burk O. Mustonen EK, et al. Among authors: pantsar t. Cells. 2022 Apr 12;11(8):1299. doi: 10.3390/cells11081299. Cells. 2022. PMID: 35455978 Free PMC article.

10

Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist.

Rashidian A, Mustonen EK, Kronenberger T, Schwab M, Burk O, Laufer SA, Pantsar T. Rashidian A, et al. Among authors: pantsar t. Comput Struct Biotechnol J. 2022 Jun 13;20:3004-3018. doi: 10.1016/j.csbj.2022.06.020. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35782743 Free PMC article.

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