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Page 1
Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens.
Lopes R, Sprouffske K, Sheng C, Uijttewaal ECH, Wesdorp AE, Dahinden J, Wengert S, Diaz-Miyar J, Yildiz U, Bleu M, Apfel V, Mermet-Meillon F, Krese R, Eder M, Olsen AV, Hoppe P, Knehr J, Carbone W, Cuttat R, Waldt A, Altorfer M, Naumann U, Weischenfeldt J, deWeck A, Kauffmann A, Roma G, Schübeler D, Galli GG. Lopes R, et al. Among authors: schubeler d. Sci Adv. 2021 Jul 2;7(27):eabf5733. doi: 10.1126/sciadv.abf5733. Print 2021 Jul. Sci Adv. 2021. PMID: 34215580 Free PMC article.
ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers.
Yelagandula R, Stecher K, Novatchkova M, Michetti L, Michlits G, Wang J, Hofbauer P, Vainorius G, Pribitzer C, Isbel L, Mendjan S, Schübeler D, Elling U, Brennecke J, Bell O. Yelagandula R, et al. Among authors: schubeler d. Nat Cell Biol. 2023 Jan;25(1):42-55. doi: 10.1038/s41556-022-01051-2. Epub 2023 Jan 5. Nat Cell Biol. 2023. PMID: 36604593 Free PMC article.
YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers.
Stein C, Bardet AF, Roma G, Bergling S, Clay I, Ruchti A, Agarinis C, Schmelzle T, Bouwmeester T, Schübeler D, Bauer A. Stein C, et al. Among authors: schubeler d. PLoS Genet. 2015 Aug 21;11(8):e1005465. doi: 10.1371/journal.pgen.1005465. eCollection 2015 Aug. PLoS Genet. 2015. PMID: 26295846 Free PMC article.
PAX8 and MECOM are interaction partners driving ovarian cancer.
Bleu M, Mermet-Meillon F, Apfel V, Barys L, Holzer L, Bachmann Salvy M, Lopes R, Amorim Monteiro Barbosa I, Delmas C, Hinniger A, Chau S, Kaufmann M, Haenni S, Berneiser K, Wahle M, Moravec I, Vissières A, Poetsch T, Ahrné E, Carte N, Voshol J, Bechter E, Hamon J, Meyerhofer M, Erdmann D, Fischer M, Stachyra T, Freuler F, Gutmann S, Fernández C, Schmelzle T, Naumann U, Roma G, Lawrenson K, Nieto-Oberhuber C, Cobos-Correa A, Ferretti S, Schübeler D, Galli GG. Bleu M, et al. Among authors: schubeler d. Nat Commun. 2021 Apr 26;12(1):2442. doi: 10.1038/s41467-021-22708-w. Nat Commun. 2021. PMID: 33903593 Free PMC article.
DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions.
Butz S, Schmolka N, Karemaker ID, Villaseñor R, Schwarz I, Domcke S, Uijttewaal ECH, Jude J, Lienert F, Krebs AR, de Wagenaar NP, Bao X, Zuber J, Elling U, Schübeler D, Baubec T. Butz S, et al. Among authors: schubeler d. Nat Genet. 2022 Nov;54(11):1702-1710. doi: 10.1038/s41588-022-01210-z. Epub 2022 Nov 4. Nat Genet. 2022. PMID: 36333500 Free PMC article.
Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens.
Barbosa IAM, Gopalakrishnan R, Mercan S, Mourikis TP, Martin T, Wengert S, Sheng C, Ji F, Lopes R, Knehr J, Altorfer M, Lindeman A, Russ C, Naumann U, Golji J, Sprouffske K, Barys L, Tordella L, Schübeler D, Schmelzle T, Galli GG. Barbosa IAM, et al. Among authors: schubeler d. Nat Commun. 2023 Jul 3;14(1):3907. doi: 10.1038/s41467-023-39527-w. Nat Commun. 2023. PMID: 37400441 Free PMC article.
Cis-regulatory landscapes of four cell types of the retina.
Hartl D, Krebs AR, Jüttner J, Roska B, Schübeler D. Hartl D, et al. Among authors: schubeler d. Nucleic Acids Res. 2017 Nov 16;45(20):11607-11621. doi: 10.1093/nar/gkx923. Nucleic Acids Res. 2017. PMID: 29059322 Free PMC article.
DNA-binding factors shape the mouse methylome at distal regulatory regions.
Stadler MB, Murr R, Burger L, Ivanek R, Lienert F, Schöler A, van Nimwegen E, Wirbelauer C, Oakeley EJ, Gaidatzis D, Tiwari VK, Schübeler D. Stadler MB, et al. Among authors: schubeler d. Nature. 2011 Dec 14;480(7378):490-5. doi: 10.1038/nature10716. Nature. 2011. PMID: 22170606
127 results