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Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice.
Garai J, Krekó M, Őrfi L, Jakus PB, Rumbus Z, Kéringer P, Garami A, Vámos E, Kovács D, Bagóné Vántus V, Radnai B, Lóránd T. Garai J, et al. Among authors: lorand t. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1357-1369. doi: 10.1080/14756366.2021.1916010. J Enzyme Inhib Med Chem. 2021. PMID: 34225560 Free PMC article.
Relationship between lipophilicity and antitumor activity of molecule library of Mannich ketones determined by high-performance liquid chromatography, clogP calculation and cytotoxicity test.
Hollósy F, Lóránd T, Orfi L, Erös D, Kéri G, Idei M. Hollósy F, et al. Among authors: lorand t. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Mar 5;768(2):361-8. doi: 10.1016/s1570-0232(02)00004-1. J Chromatogr B Analyt Technol Biomed Life Sci. 2002. PMID: 11888064
Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
Radnai B, Antus C, Racz B, Engelmann P, Priber JK, Tucsek Z, Veres B, Turi Z, Lorand T, Sumegi B, Gallyas F Jr. Radnai B, et al. Among authors: lorand t. Mol Cancer. 2012 May 14;11:34. doi: 10.1186/1476-4598-11-34. Mol Cancer. 2012. PMID: 22583868 Free PMC article.
Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice.
Garai J, Radnai B, Vámos E, Kovács D, Vántus VB, Rumbus Z, Pákai E, Garami A, Gulyás-Fekete G, Agócs A, Krekó M, Zaman K, Prókai L, Őrfi L, Jakus PB, Lóránd T. Garai J, et al. Among authors: lorand t. Eur J Med Chem. 2023 Feb 5;247:115050. doi: 10.1016/j.ejmech.2022.115050. Epub 2022 Dec 28. Eur J Med Chem. 2023. PMID: 36587420 Free article.
Synthesis and antibacterial activity of fused Mannich ketones.
Lóránd T, Kocsis B, Sohár P, Nagy G, József P, Kispál G, László R, Prókai L. Lóránd T, et al. Eur J Med Chem. 2002 Oct;37(10):803-12. doi: 10.1016/s0223-5234(02)01404-6. Eur J Med Chem. 2002. PMID: 12446038
46 results