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Page 1
Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques.
Van Rompay KKA, Olstad KJ, Sammak RL, Dutra J, Watanabe JK, Usachenko JL, Immareddy R, Verma A, Shaan Lakshmanappa Y, Schmidt BA, Roh JW, Elizaldi SR, Allen AM, Muecksch F, Lorenzi JCC, Lockwood S, Pollard RE, Yee JL, Nham PB, Ardeshir A, Deere JD, Patterson J, Dang Q, Hatziioannou T, Bieniasz PD, Iyer SS, Hartigan-O'Connor DJ, Nussenzweig MC, Reader JR. Van Rompay KKA, et al. Among authors: lorenzi jcc. PLoS Pathog. 2021 Jul 6;17(7):e1009688. doi: 10.1371/journal.ppat.1009688. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34228761 Free PMC article.
Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies.
Barnes CO, West AP Jr, Huey-Tubman KE, Hoffmann MAG, Sharaf NG, Hoffman PR, Koranda N, Gristick HB, Gaebler C, Muecksch F, Lorenzi JCC, Finkin S, Hägglöf T, Hurley A, Millard KG, Weisblum Y, Schmidt F, Hatziioannou T, Bieniasz PD, Caskey M, Robbiani DF, Nussenzweig MC, Bjorkman PJ. Barnes CO, et al. Among authors: lorenzi jcc. Cell. 2020 Aug 20;182(4):828-842.e16. doi: 10.1016/j.cell.2020.06.025. Epub 2020 Jun 24. Cell. 2020. PMID: 32645326 Free PMC article.
Convergent antibody responses to SARS-CoV-2 in convalescent individuals.
Robbiani DF, Gaebler C, Muecksch F, Lorenzi JCC, Wang Z, Cho A, Agudelo M, Barnes CO, Gazumyan A, Finkin S, Hägglöf T, Oliveira TY, Viant C, Hurley A, Hoffmann HH, Millard KG, Kost RG, Cipolla M, Gordon K, Bianchini F, Chen ST, Ramos V, Patel R, Dizon J, Shimeliovich I, Mendoza P, Hartweger H, Nogueira L, Pack M, Horowitz J, Schmidt F, Weisblum Y, Michailidis E, Ashbrook AW, Waltari E, Pak JE, Huey-Tubman KE, Koranda N, Hoffman PR, West AP Jr, Rice CM, Hatziioannou T, Bjorkman PJ, Bieniasz PD, Caskey M, Nussenzweig MC. Robbiani DF, et al. Among authors: lorenzi jcc. Nature. 2020 Aug;584(7821):437-442. doi: 10.1038/s41586-020-2456-9. Epub 2020 Jun 18. Nature. 2020. PMID: 32555388 Free PMC article.
Enhanced SARS-CoV-2 neutralization by dimeric IgA.
Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Viant C, Gaebler C, Cipolla M, Hoffmann HH, Oliveira TY, Oren DA, Ramos V, Nogueira L, Michailidis E, Robbiani DF, Gazumyan A, Rice CM, Hatziioannou T, Bieniasz PD, Caskey M, Nussenzweig MC. Wang Z, et al. Among authors: lorenzi jcc. Sci Transl Med. 2021 Jan 20;13(577):eabf1555. doi: 10.1126/scitranslmed.abf1555. Epub 2020 Dec 7. Sci Transl Med. 2021. PMID: 33288661 Free PMC article.
Evolution of antibody immunity to SARS-CoV-2.
Gaebler C, Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Tokuyama M, Cho A, Jankovic M, Schaefer-Babajew D, Oliveira TY, Cipolla M, Viant C, Barnes CO, Bram Y, Breton G, Hägglöf T, Mendoza P, Hurley A, Turroja M, Gordon K, Millard KG, Ramos V, Schmidt F, Weisblum Y, Jha D, Tankelevich M, Martinez-Delgado G, Yee J, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Robbiani DF, Zhao Z, Gazumyan A, Schwartz RE, Hatziioannou T, Bjorkman PJ, Mehandru S, Bieniasz PD, Caskey M, Nussenzweig MC. Gaebler C, et al. Among authors: lorenzi jcc. Nature. 2021 Mar;591(7851):639-644. doi: 10.1038/s41586-021-03207-w. Epub 2021 Jan 18. Nature. 2021. PMID: 33461210 Free PMC article.
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses.
Schmidt F, Weisblum Y, Muecksch F, Hoffmann HH, Michailidis E, Lorenzi JCC, Mendoza P, Rutkowska M, Bednarski E, Gaebler C, Agudelo M, Cho A, Wang Z, Gazumyan A, Cipolla M, Caskey M, Robbiani DF, Nussenzweig MC, Rice CM, Hatziioannou T, Bieniasz PD. Schmidt F, et al. Among authors: lorenzi jcc. bioRxiv [Preprint]. 2020 Jun 9:2020.06.08.140871. doi: 10.1101/2020.06.08.140871. bioRxiv. 2020. Update in: J Exp Med. 2020 Nov 2;217(11):e20201181. doi: 10.1084/jem.20201181 PMID: 32577658 Free PMC article. Updated. Preprint.
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses.
Schmidt F, Weisblum Y, Muecksch F, Hoffmann HH, Michailidis E, Lorenzi JCC, Mendoza P, Rutkowska M, Bednarski E, Gaebler C, Agudelo M, Cho A, Wang Z, Gazumyan A, Cipolla M, Caskey M, Robbiani DF, Nussenzweig MC, Rice CM, Hatziioannou T, Bieniasz PD. Schmidt F, et al. Among authors: lorenzi jcc. J Exp Med. 2020 Nov 2;217(11):e20201181. doi: 10.1084/jem.20201181. J Exp Med. 2020. PMID: 32692348 Free PMC article.
Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients.
Muecksch F, Wise H, Batchelor B, Squires M, Semple E, Richardson C, McGuire J, Clearly S, Furrie E, Greig N, Hay G, Templeton K, Lorenzi JCC, Hatziioannou T, Jenks S, Bieniasz PD. Muecksch F, et al. Among authors: lorenzi jcc. J Infect Dis. 2021 Feb 13;223(3):389-398. doi: 10.1093/infdis/jiaa659. J Infect Dis. 2021. PMID: 33140086 Free PMC article.
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo.
Schäfer A, Muecksch F, Lorenzi JCC, Leist SR, Cipolla M, Bournazos S, Schmidt F, Maison RM, Gazumyan A, Martinez DR, Baric RS, Robbiani DF, Hatziioannou T, Ravetch JV, Bieniasz PD, Bowen RA, Nussenzweig MC, Sheahan TP. Schäfer A, et al. Among authors: lorenzi jcc. J Exp Med. 2021 Mar 1;218(3):e20201993. doi: 10.1084/jem.20201993. J Exp Med. 2021. PMID: 33211088 Free PMC article.
Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.
De Gasparo R, Pedotti M, Simonelli L, Nickl P, Muecksch F, Cassaniti I, Percivalle E, Lorenzi JCC, Mazzola F, Magrì D, Michalcikova T, Haviernik J, Honig V, Mrazkova B, Polakova N, Fortova A, Tureckova J, Iatsiuk V, Di Girolamo S, Palus M, Zudova D, Bednar P, Bukova I, Bianchini F, Mehn D, Nencka R, Strakova P, Pavlis O, Rozman J, Gioria S, Sammartino JC, Giardina F, Gaiarsa S, Pan-Hammarström Q, Barnes CO, Bjorkman PJ, Calzolai L, Piralla A, Baldanti F, Nussenzweig MC, Bieniasz PD, Hatziioannou T, Prochazka J, Sedlacek R, Robbiani DF, Ruzek D, Varani L. De Gasparo R, et al. Among authors: lorenzi jcc. Nature. 2021 May;593(7859):424-428. doi: 10.1038/s41586-021-03461-y. Epub 2021 Mar 25. Nature. 2021. PMID: 33767445
54 results