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Loss of mTORC2 Activity in Neutrophils Impairs Fusion of Granules and Affects Cellular Metabolism Favoring Increased Bacterial Burden in Sepsis.
Breda CNS, Breda LCD, Carvalho LADC, Amano MT, Terra FF, Silva RC, Fragas MG, Forni MF, Fonseca MTC, Venturini G, Feitosa ACM, Ghirotto B, Cruz MC, Cunha FF, Ignacio A, Latância M, Castoldi A, Andrade-Oliveira V, Martins da Silva E, Hiyane MI, Pereira ADC, Festuccia W, Meotti FC, Câmara NOS. Breda CNS, et al. Among authors: festuccia w. J Immunol. 2021 Jul 15;207(2):626-639. doi: 10.4049/jimmunol.2000573. Epub 2021 Jul 14. J Immunol. 2021. PMID: 34261666
Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.
Chimin P, Andrade ML, Belchior T, Paschoal VA, Magdalon J, Yamashita AS, Castro É, Castoldi A, Chaves-Filho AB, Yoshinaga MY, Miyamoto S, Câmara NO, Festuccia WT. Chimin P, et al. J Lipid Res. 2017 Sep;58(9):1797-1807. doi: 10.1194/jlr.M074518. Epub 2017 Jul 5. J Lipid Res. 2017. PMID: 28679588 Free PMC article.
Depletion of Ric-8B leads to reduced mTORC2 activity.
Nagai MH, Xavier VPS, Gutiyama LM, Machado CF, Reis AH, Donnard ER, Galante PAF, Abreu JG, Festuccia WT, Malnic B. Nagai MH, et al. PLoS Genet. 2020 May 11;16(5):e1008255. doi: 10.1371/journal.pgen.1008255. eCollection 2020 May. PLoS Genet. 2020. PMID: 32392211 Free PMC article.
PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity.
Andrade ML, Gilio GR, Perandini LA, Peixoto AS, Moreno MF, Castro É, Oliveira TE, Vieira TS, Ortiz-Silva M, Thomazelli CA, Chaves-Filho AB, Belchior T, Chimin P, Magdalon J, Ivison R, Pant D, Tsai L, Yoshinaga MY, Miyamoto S, Festuccia WT. Andrade ML, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158967. doi: 10.1016/j.bbalip.2021.158967. Epub 2021 May 15. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 34004356 Free PMC article.
Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice.
Castro É, Vieira TS, Oliveira TE, Ortiz-Silva M, Andrade ML, Tomazelli CA, Peixoto AS, Sobrinho CR, Moreno MF, Gilio GR, Moreira RJ, Guimarães RC, Perandini LA, Chimin P, Reckziegel P, Moretti EH, Steiner AA, Laplante M, Festuccia WT. Castro É, et al. Am J Physiol Endocrinol Metab. 2021 Nov 1;321(5):E592-E605. doi: 10.1152/ajpendo.00587.2020. Epub 2021 Sep 20. Am J Physiol Endocrinol Metab. 2021. PMID: 34541875 Free article.
101 results