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Multivalent designed proteins protect against SARS-CoV-2 variants of concern.
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vögeli B, Krüger-Gericke A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken S, Ljubetič A, Edman N, Ueda G, Chow C, Addetia A, Panpradist N, Gale M Jr, Freedman BS, Lutz BR, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D. Hunt AC, et al. Among authors: jewett mc. bioRxiv [Preprint]. 2021 Jul 7:2021.07.07.451375. doi: 10.1101/2021.07.07.451375. bioRxiv. 2021. Update in: Sci Transl Med. 2022 May 25;14(646):eabn1252. doi: 10.1126/scitranslmed.abn1252 PMID: 34268509 Free PMC article. Updated. Preprint.
De novo design of protein logic gates.
Chen Z, Kibler RD, Hunt A, Busch F, Pearl J, Jia M, VanAernum ZL, Wicky BIM, Dods G, Liao H, Wilken MS, Ciarlo C, Green S, El-Samad H, Stamatoyannopoulos J, Wysocki VH, Jewett MC, Boyken SE, Baker D. Chen Z, et al. Among authors: jewett mc. Science. 2020 Apr 3;368(6486):78-84. doi: 10.1126/science.aay2790. Science. 2020. PMID: 32241946 Free PMC article.
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice.
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vögeli B, Krüger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetič A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale M Jr, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D. Hunt AC, et al. Among authors: jewett mc. Sci Transl Med. 2022 May 25;14(646):eabn1252. doi: 10.1126/scitranslmed.abn1252. Epub 2022 May 25. Sci Transl Med. 2022. PMID: 35412328 Free PMC article.
Rapid and Sensitive Detection of Antigen from SARS-CoV-2 Variants of Concern by a Multivalent Minibinder-Functionalized Nanomechanical Sensor.
Agarwal DK, Hunt AC, Shekhawat GS, Carter L, Chan S, Wu K, Cao L, Baker D, Lorenzo-Redondo R, Ozer EA, Simons LM, Hultquist JF, Jewett MC, Dravid VP. Agarwal DK, et al. Among authors: jewett mc. Anal Chem. 2022 Jun 14;94(23):8105-8109. doi: 10.1021/acs.analchem.2c01221. Epub 2022 Jun 2. Anal Chem. 2022. PMID: 35652578 Free PMC article.
A rapid cell-free expression and screening platform for antibody discovery.
Hunt AC, Vögeli B, Hassan AO, Guerrero L, Kightlinger W, Yoesep DJ, Krüger A, DeWinter M, Diamond MS, Karim AS, Jewett MC. Hunt AC, et al. Among authors: jewett mc. Nat Commun. 2023 Jul 3;14(1):3897. doi: 10.1038/s41467-023-38965-w. Nat Commun. 2023. PMID: 37400446 Free PMC article.
Cell-Free Gene Expression: Methods and Applications.
Hunt AC, Rasor BJ, Seki K, Ekas HM, Warfel KF, Karim AS, Jewett MC. Hunt AC, et al. Among authors: jewett mc. Chem Rev. 2024 Dec 19. doi: 10.1021/acs.chemrev.4c00116. Online ahead of print. Chem Rev. 2024. PMID: 39700225 Review.
At-home, cell-free synthetic biology education modules for transcriptional regulation and environmental water quality monitoring.
Jung KJ, Rasor BJ, Rybnicky GA, Silverman AD, Standeven J, Kuhn R, Granito T, Ekas HM, Wang BM, Karim AS, Lucks JB, Jewett MC. Jung KJ, et al. Among authors: jewett mc. bioRxiv [Preprint]. 2023 Jan 9:2023.01.09.523248. doi: 10.1101/2023.01.09.523248. bioRxiv. 2023. Update in: ACS Synth Biol. 2023 Oct 20;12(10):2909-2921. doi: 10.1021/acssynbio.3c00223 PMID: 36711593 Free PMC article. Updated. Preprint.
Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in Escherichia coli.
Sotomayor B, Donahue TC, Mahajan SP, Taw MN, Hulbert SW, Bidstrup EJ, Owitipana DN, Pang A, Yang X, Ghosal S, Alabi CA, Azadi P, Gray JJ, Jewett MC, Wang LX, DeLisa MP. Sotomayor B, et al. Among authors: jewett mc. bioRxiv [Preprint]. 2024 Nov 10:2024.08.12.607630. doi: 10.1101/2024.08.12.607630. bioRxiv. 2024. PMID: 39574765 Free PMC article. Preprint.
219 results