Pfaffinger D - Search Results

1

Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.

Hamilton MM, Mseeh F, McAfoos TJ, Leonard PG, Reyna NJ, Harris AL, Xu A, Han M, Soth MJ, Czako B, Theroff JP, Mandal PK, Burke JP, Virgin-Downey B, Petrocchi A, Pfaffinger D, Rogers NE, Parker CA, Yu SS, Jiang Y, Krapp S, Lammens A, Trevitt G, Tremblay MR, Mikule K, Wilcoxen K, Cross JB, Jones P, Marszalek JR, Lewis RT. Hamilton MM, et al. Among authors: pfaffinger d. J Med Chem. 2021 Aug 12;64(15):11302-11329. doi: 10.1021/acs.jmedchem.1c00679. Epub 2021 Jul 22. J Med Chem. 2021. PMID: 34292726

2

Enantioselective Ruthenium-BINAP-Catalyzed Carbonyl Reductive Coupling of Alkoxyallenes: Convergent Construction of syn-sec,tert-Diols via (Z)-σ-Allylmetal Intermediates.

Xiang M, Pfaffinger DE, Ortiz E, Brito GA, Krische MJ. Xiang M, et al. Among authors: pfaffinger de. J Am Chem Soc. 2021 Jun 16;143(23):8849-8854. doi: 10.1021/jacs.1c03480. Epub 2021 Jun 1. J Am Chem Soc. 2021. PMID: 34060818 Free PMC article.

3

Allenes and Dienes as Chiral Allylmetal Pronucleophiles in Catalytic Enantioselective C=X Addition: Historical Perspective and State-of-The-Art Survey.

Xiang M, Pfaffinger DE, Krische MJ. Xiang M, et al. Among authors: pfaffinger de. Chemistry. 2021 Sep 15;27(52):13107-13116. doi: 10.1002/chem.202101890. Epub 2021 Jul 29. Chemistry. 2021. PMID: 34185926 Free PMC article. Review.

4

Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts.

Edelstein C, Pfaffinger D, Yang M, Hill JS, Scanu AM. Edelstein C, et al. Among authors: pfaffinger d. Biochim Biophys Acta. 2010 Jul;1801(7):738-45. doi: 10.1016/j.bbalip.2010.03.009. Epub 2010 Mar 24. Biochim Biophys Acta. 2010. PMID: 20346413 Free PMC article.

5

Mouse plasminogen has oxidized phosphatidylcholine adducts that are not metabolized by lipoprotein-associated phospholipase A₂under basal conditions.

Edelstein C, Pfaffinger D, Reichert EC, Stafforini DM, Scanu AM. Edelstein C, et al. Among authors: pfaffinger d. Int J Mol Sci. 2010;11(12):5339-47. doi: 10.3390/ijms11125339. Epub 2010 Dec 22. Int J Mol Sci. 2010. PMID: 21614211 Free PMC article.

6

Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.

Ober C, Nord AS, Thompson EE, Pan L, Tan Z, Cusanovich D, Sun Y, Nicolae R, Edelstein C, Schneider DH, Billstrand C, Pfaffinger D, Phillips N, Anderson RL, Philips B, Rajagopalan R, Hatsukami TS, Rieder MJ, Heagerty PJ, Nickerson DA, Abney M, Marcovina S, Jarvik GP, Scanu AM, Nicolae DL. Ober C, et al. Among authors: pfaffinger d. J Lipid Res. 2009 May;50(5):798-806. doi: 10.1194/jlr.M800515-JLR200. Epub 2009 Jan 5. J Lipid Res. 2009. PMID: 19124843 Free PMC article.

7

The oxidized phospholipids linked to human apolipoprotein(a) do not derive from circulating low-density lipoproteins and are probably of cellular origin.

Edelstein C, Philips B, Pfaffinger D, Scanu AM. Edelstein C, et al. Among authors: pfaffinger d. FASEB J. 2009 Mar;23(3):950-6. doi: 10.1096/fj.08-122002. Epub 2008 Nov 10. FASEB J. 2009. PMID: 19001055 Free PMC article.

8

Successful utilization of lyophilized lipoprotein(a) as a biological reagent.

Scanu AM, Hinman J, Pfaffinger D, Edelstein C. Scanu AM, et al. Among authors: pfaffinger d. Lipids. 2004 Jun;39(6):589-93. doi: 10.1007/s11745-004-1268-5. Lipids. 2004. PMID: 15554160

9

Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a).

Edelstein C, Pfaffinger D, Hinman J, Miller E, Lipkind G, Tsimikas S, Bergmark C, Getz GS, Witztum JL, Scanu AM. Edelstein C, et al. Among authors: pfaffinger d. J Biol Chem. 2003 Dec 26;278(52):52841-7. doi: 10.1074/jbc.M310425200. Epub 2003 Oct 13. J Biol Chem. 2003. PMID: 14557258 Free article.

10

Oxidative events cause degradation of apoB-100 but not of apo[a] and facilitate enzymatic cleavage of both proteins.

Edelstein C, Nakajima K, Pfaffinger D, Scanu AM. Edelstein C, et al. Among authors: pfaffinger d. J Lipid Res. 2001 Oct;42(10):1664-70. J Lipid Res. 2001. PMID: 11590223 Free article.

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