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Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
Brien GL, Bressan RB, Monger C, Gannon D, Lagan E, Doherty AM, Healy E, Neikes H, Fitzpatrick DJ, Deevy O, Grant V, Marqués-Torrejón MA, Alfazema N, Pollard SM, Bracken AP. Brien GL, et al. Among authors: bracken ap. Nat Genet. 2021 Aug;53(8):1221-1232. doi: 10.1038/s41588-021-00897-w. Epub 2021 Jul 22. Nat Genet. 2021. PMID: 34294917
A model for transmission of the H3K27me3 epigenetic mark.
Hansen KH, Bracken AP, Pasini D, Dietrich N, Gehani SS, Monrad A, Rappsilber J, Lerdrup M, Helin K. Hansen KH, et al. Among authors: bracken ap. Nat Cell Biol. 2008 Nov;10(11):1291-300. doi: 10.1038/ncb1787. Epub 2008 Oct 19. Nat Cell Biol. 2008. PMID: 18931660
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.
Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP. Brien GL, et al. Among authors: bracken ap. Nat Struct Mol Biol. 2012 Dec;19(12):1273-81. doi: 10.1038/nsmb.2449. Epub 2012 Nov 18. Nat Struct Mol Biol. 2012. PMID: 23160351
Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients.
Lanigan F, Brien GL, Fan Y, Madden SF, Jerman E, Maratha A, Aloraifi F, Hokamp K, Dunne EJ, Lohan AJ, Flanagan L, Garbe JC, Stampfer MR, Fridberg M, Jirstrom K, Quinn CM, Loftus B, Gallagher WM, Geraghty J, Bracken AP. Lanigan F, et al. Among authors: bracken ap. FEBS J. 2015 Sep;282(18):3455-73. doi: 10.1111/febs.13354. Epub 2015 Jul 14. FEBS J. 2015. PMID: 26094870 Free article.
A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP. Brien GL, et al. Among authors: bracken ap. Genes Dev. 2015 Nov 1;29(21):2231-43. doi: 10.1101/gad.267930.115. Epub 2015 Oct 22. Genes Dev. 2015. PMID: 26494712 Free PMC article.
58 results