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Page 1
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
Brien GL, Bressan RB, Monger C, Gannon D, Lagan E, Doherty AM, Healy E, Neikes H, Fitzpatrick DJ, Deevy O, Grant V, Marqués-Torrejón MA, Alfazema N, Pollard SM, Bracken AP. Brien GL, et al. Among authors: marques torrejon ma. Nat Genet. 2021 Aug;53(8):1221-1232. doi: 10.1038/s41588-021-00897-w. Epub 2021 Jul 22. Nat Genet. 2021. PMID: 34294917
Give it a REST!
Pollard SM, Marques-Torrejon MA. Pollard SM, et al. Elife. 2016 Jan 8;5:e12615. doi: 10.7554/eLife.12615. Elife. 2016. PMID: 26745186 Free PMC article.
Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators.
Bulstrode H, Johnstone E, Marques-Torrejon MA, Ferguson KM, Bressan RB, Blin C, Grant V, Gogolok S, Gangoso E, Gagrica S, Ender C, Fotaki V, Sproul D, Bertone P, Pollard SM. Bulstrode H, et al. Genes Dev. 2017 Apr 15;31(8):757-773. doi: 10.1101/gad.293027.116. Epub 2017 May 2. Genes Dev. 2017. PMID: 28465359 Free PMC article.
Experimental models and tools to tackle glioblastoma.
Robertson FL, Marqués-Torrejón MA, Morrison GM, Pollard SM. Robertson FL, et al. Dis Model Mech. 2019 Sep 6;12(9):dmm040386. doi: 10.1242/dmm.040386. Dis Model Mech. 2019. PMID: 31519690 Free PMC article. Review.
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants.
Bressan RB, Southgate B, Ferguson KM, Blin C, Grant V, Alfazema N, Wills JC, Marques-Torrejon MA, Morrison GM, Ashmore J, Robertson F, Williams CAC, Bradley L, von Kriegsheim A, Anderson RA, Tomlinson SR, Pollard SM. Bressan RB, et al. Cell Stem Cell. 2021 May 6;28(5):877-893.e9. doi: 10.1016/j.stem.2021.01.016. Epub 2021 Feb 24. Cell Stem Cell. 2021. PMID: 33631116 Free PMC article.
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Gangoso E, Southgate B, Bradley L, Rus S, Galvez-Cancino F, McGivern N, Güç E, Kapourani CA, Byron A, Ferguson KM, Alfazema N, Morrison G, Grant V, Blin C, Sou I, Marques-Torrejon MA, Conde L, Parrinello S, Herrero J, Beck S, Brandner S, Brennan PM, Bertone P, Pollard JW, Quezada SA, Sproul D, Frame MC, Serrels A, Pollard SM. Gangoso E, et al. Cell. 2021 Apr 29;184(9):2454-2470.e26. doi: 10.1016/j.cell.2021.03.023. Epub 2021 Apr 14. Cell. 2021. PMID: 33857425 Free PMC article.
LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells.
Marqués-Torrejón MÁ, Williams CAC, Southgate B, Alfazema N, Clements MP, Garcia-Diaz C, Blin C, Arranz-Emparan N, Fraser J, Gammoh N, Parrinello S, Pollard SM. Marqués-Torrejón MÁ, et al. Nat Commun. 2021 May 10;12(1):2594. doi: 10.1038/s41467-021-22813-w. Nat Commun. 2021. PMID: 33972529 Free PMC article.
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