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The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action.
Finci LI, Zhang X, Huang X, Zhou Q, Tsai J, Teng T, Agrawal A, Chan B, Irwin S, Karr C, Cook A, Zhu P, Reynolds D, Smith PG, Fekkes P, Buonamici S, Larsen NA. Finci LI, et al. Among authors: cook a. Genes Dev. 2018 Feb 1;32(3-4):309-320. doi: 10.1101/gad.311043.117. Genes Dev. 2018. PMID: 29491137 Free PMC article.
Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.
Cretu C, Agrawal AA, Cook A, Will CL, Fekkes P, Smith PG, Lührmann R, Larsen N, Buonamici S, Pena V. Cretu C, et al. Among authors: cook a. Mol Cell. 2018 Apr 19;70(2):265-273.e8. doi: 10.1016/j.molcel.2018.03.011. Epub 2018 Apr 12. Mol Cell. 2018. PMID: 29656923 Free article.
Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3.
Brawn RA, Cook A, Omoto K, Ke J, Karr C, Colombo F, Virrankoski M, Prajapati S, Reynolds D, Bolduc DM, Nguyen TV, Gee P, Borrelli D, Caleb B, Yao S, Irwin S, Larsen NA, Selvaraj A, Zhao X, Ioannidis S. Brawn RA, et al. Among authors: cook a. ACS Med Chem Lett. 2020 Dec 2;12(1):93-98. doi: 10.1021/acsmedchemlett.0c00517. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488969 Free PMC article.
Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1.
Rolfe A, Yao S, Nguyen TV, Omoto K, Colombo F, Virrankoski M, Vaillancourt FH, Yu L, Cook A, Reynolds D, Ioannidis S, Zhu P, Larsen NA, Bolduc DM. Rolfe A, et al. Among authors: cook a. ACS Med Chem Lett. 2020 May 26;11(6):1305-1309. doi: 10.1021/acsmedchemlett.0c00145. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32551016 Free PMC article.
Multiwavelength constraints on the origin of a nearby repeating fast radio burst source in a globular cluster.
Pearlman AB, Scholz P, Bethapudi S, Hessels JWT, Kaspi VM, Kirsten F, Nimmo K, Spitler LG, Fonseca E, Meyers BW, Stairs IH, Tan CM, Bhardwaj M, Chatterjee S, Cook AM, Curtin AP, Dong FA, Eftekhari T, Gaensler BM, Güver T, Kaczmarek J, Leung C, Masui KW, Michilli D, Prince TA, Sand KR, Shin K, Smith KM, Tendulkar SP. Pearlman AB, et al. Among authors: cook am. Nat Astron. 2025;9(1):111-127. doi: 10.1038/s41550-024-02386-6. Epub 2024 Nov 26. Nat Astron. 2025. PMID: 39866549 Free PMC article.
3,422 results