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Page 1
Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells.
Beauvarlet J, Nath Das R, Alvarez-Valadez K, Martins I, Muller A, Darbo E, Richard E, Soubeyran P, Kroemer G, Guillon J, Mergny JL, Djavaheri-Mergny M. Beauvarlet J, et al. Among authors: alvarez valadez k. Cancers (Basel). 2020 Jun 18;12(6):1621. doi: 10.3390/cancers12061621. Cancers (Basel). 2020. PMID: 32570977 Free PMC article.
ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis.
Motiño O, Lambertucci F, Anagnostopoulos G, Li S, Nah J, Castoldi F, Senovilla L, Montégut L, Chen H, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Alvarez-Valadez K, Sauvat A, Carbonnier V, Djavaheri-Mergny M, Pietrocola F, Sadoshima J, Maiuri MC, Martins I, Kroemer G. Motiño O, et al. Among authors: alvarez valadez k. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2207344119. doi: 10.1073/pnas.2207344119. Epub 2022 Oct 3. Proc Natl Acad Sci U S A. 2022. PMID: 36191214 Free PMC article.
Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death.
Alvarez-Valadez K, Sauvat A, Diharce J, Leduc M, Stoll G, Guittat L, Lambertucci F, Paillet J, Motiño O, Ferret L, Muller A, Forveille S, Maiuri MC, Kepp O, de Brevern AG, Wodrich H, Pol JG, Kroemer G, Djavaheri-Mergny M. Alvarez-Valadez K, et al. Autophagy. 2024 Dec 27:1-23. doi: 10.1080/15548627.2024.2440842. Online ahead of print. Autophagy. 2024. PMID: 39663580
Inhibition of acyl-CoA binding protein (ACBP) by means of a GABAARγ2-derived peptide.
Anagnostopoulos G, Saavedra E, Lambertucci F, Motiño O, Dimitrov J, Roiz-Valle D, Quesada V, Alvarez-Valadez K, Chen H, Sauvat A, Rong Y, Nogueira-Recalde U, Li S, Montégut L, Djavaheri-Mergny M, Castedo M, Lopez-Otin C, Maiuri MC, Martins I, Kroemer G. Anagnostopoulos G, et al. Among authors: alvarez valadez k. Cell Death Dis. 2024 Apr 6;15(4):249. doi: 10.1038/s41419-024-06633-6. Cell Death Dis. 2024. PMID: 38582872 Free PMC article.
IMMUNEPOTENT CRP increases intracellular calcium through ER-calcium channels, leading to ROS production and cell death in breast cancer and leukemic cell lines.
Lorenzo-Anota HY, Reyes-Ruiz A, Calvillo-Rodríguez KM, Mendoza-Reveles R, Urdaneta-Peinado AP, Alvarez-Valadez KM, Martínez-Torres AC, Rodríguez-Padilla C. Lorenzo-Anota HY, et al. Among authors: alvarez valadez km. EXCLI J. 2023 Mar 16;22:352-366. doi: 10.17179/excli2022-5568. eCollection 2023. EXCLI J. 2023. PMID: 37223080 Free PMC article.
G-quadruplex ligands as potent regulators of lysosomes.
Ferret L, Alvarez-Valadez K, Rivière J, Muller A, Bohálová N, Yu L, Guittat L, Brázda V, Kroemer G, Mergny JL, Djavaheri-Mergny M. Ferret L, et al. Among authors: alvarez valadez k. Autophagy. 2023 Jul;19(7):1901-1915. doi: 10.1080/15548627.2023.2170071. Epub 2023 Feb 5. Autophagy. 2023. PMID: 36740766 Free PMC article.