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Page 1
Pharmacokinetics and safety of niraparib in patients with moderate hepatic impairment.
Akce M, El-Khoueiry A, Piha-Paul SA, Bacque E, Pan P, Zhang ZY, Ewesuedo R, Gupta D, Tang Y, Milton A, Zajic S, Judson PL, O'Bryant CL. Akce M, et al. Among authors: bacque e. Cancer Chemother Pharmacol. 2021 Nov;88(5):825-836. doi: 10.1007/s00280-021-04329-8. Epub 2021 Jul 29. Cancer Chemother Pharmacol. 2021. PMID: 34324028 Free PMC article. Clinical Trial.
Niraparib, Dostarlimab, and Bevacizumab as Combination Therapy in Pretreated, Advanced Platinum-Resistant Ovarian Cancer: Findings From Cohort A of the OPAL Phase II Trial.
Liu JF, Gaillard S, Wahner Hendrickson AE, Yeku O, Diver E, Gunderson Jackson C, Arend R, Ratner E, Samnotra V, Gupta D, Chung J, Zhang H, Compton N, Baines A, Bacqué E, Liu X, Felicetti B, Konecny GE. Liu JF, et al. Among authors: bacque e. JCO Precis Oncol. 2024 May;8:e2300693. doi: 10.1200/PO.23.00693. JCO Precis Oncol. 2024. PMID: 38754056 Free PMC article. Clinical Trial.
Health-related quality of life in patients with newly diagnosed advanced ovarian cancer treated with niraparib vs placebo: Results from the phase 3 randomized PRIMA/ENGOT-OV26/GOG-3012 trial.
Pothuri B, Han S, Chase DM, Heitz F, Burger RA, Gaba L, Van Le L, Guerra E, Bender D, Korach J, Cloven N, Churruca C, Follana P, DiSilvestro P, Baurain JF, Jardon K, Pisano C, Peen U, Mäenpää J, Gupta D, Bacqué E, Li Y, Compton N, Antonova J, Monk BJ, González-Martín A. Pothuri B, et al. Among authors: bacque e. Gynecol Oncol. 2024 May;184:168-177. doi: 10.1016/j.ygyno.2024.01.021. Epub 2024 Feb 6. Gynecol Oncol. 2024. PMID: 38325276 Free article. Clinical Trial.
In Vivo Activity Profiling of Biosynthetic Darobactin D22 against Critical Gram-Negative Pathogens.
Kany AM, Fries F, Seyfert CE, Porten C, Deckarm S, Chacón Ortiz M, Dubarry N, Vaddi S, Große M, Bernecker S, Sandargo B, Müller AV, Bacqué E, Stadler M, Herrmann J, Müller R. Kany AM, et al. Among authors: bacque e. ACS Infect Dis. 2024 Dec 13;10(12):4337-4346. doi: 10.1021/acsinfecdis.4c00687. Epub 2024 Nov 20. ACS Infect Dis. 2024. PMID: 39565008 Free PMC article.
Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861.
Kohnhäuser D, Seedorf T, Cirnski K, Heimann D, Coetzee J, Sordello S, Richter J, Stappert M, Sabuco JF, Corbett D, Bacqué E, Rox K, Herrmann J, Vassort A, Müller R, Kirschning A, Brönstrup M. Kohnhäuser D, et al. Among authors: bacque e. J Med Chem. 2024 Oct 10;67(19):17162-17190. doi: 10.1021/acs.jmedchem.4c00927. Epub 2024 Sep 20. J Med Chem. 2024. PMID: 39303218 Free PMC article.
Studies of antibacterial activity (in vitro and in vivo) and mode of action for des-acyl tridecaptins (DATs).
Couturier C, Ronzon Q, Lattanzi G, Lingard I, Coyne S, Cazals V, Dubarry N, Yvon S, Leroi-Geissler C, Gracia OR, Teague J, Sordello S, Corbett D, Bauch C, Monlong C, Payne L, Taillier T, Fuchs H, Broenstrup M, Harrison PH, Moynié L, Lakshminarayanan A, Gianga TM, Hussain R, Naismith JH, Mourez M, Bacqué E, Björkling F, Sabuco JF, Franzyk H. Couturier C, et al. Among authors: bacque e. Eur J Med Chem. 2024 Feb 5;265:116097. doi: 10.1016/j.ejmech.2023.116097. Epub 2023 Dec 23. Eur J Med Chem. 2024. PMID: 38157595
Optimization of the Antibacterial Spectrum and the Developability Profile of the Novel-Class Natural Product Corramycin.
Renard S, Versluys S, Taillier T, Dubarry N, Leroi-Geissler C, Rey A, Cornaire E, Sordello S, Carry JB, Angouillant-Boniface O, Gouyon T, Thompson F, Lebourg G, Certal V, Balazs L, Arranz E, Doerflinger G, Bretin F, Gervat V, Brohan E, Kraft V, Boulenc X, Ducelier C, Bacqué E, Couturier C. Renard S, et al. Among authors: bacque e. J Med Chem. 2023 Dec 28;66(24):16869-16887. doi: 10.1021/acs.jmedchem.3c01564. Epub 2023 Dec 13. J Med Chem. 2023. PMID: 38088830
Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas.
Ottavi S, Li K, Cacioppo JG, Perkowski AJ, Ramesh R, Gold BS, Ling Y, Roberts J, Singh A, Zhang D, Mosior J, Goullieux L, Roubert C, Bacqué E, Sacchettini JC, Nathan CF, Aubé J. Ottavi S, et al. Among authors: bacque e. ACS Med Chem Lett. 2023 Jun 26;14(7):970-976. doi: 10.1021/acsmedchemlett.3c00162. eCollection 2023 Jul 13. ACS Med Chem Lett. 2023. PMID: 37465309 Free PMC article.
Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin.
Couturier C, Groß S, von Tesmar A, Hoffmann J, Deckarm S, Fievet A, Dubarry N, Taillier T, Pöverlein C, Stump H, Kurz M, Toti L, Haag Richter S, Schummer D, Sizun P, Hoffmann M, Prasad Awal R, Zaburannyi N, Harmrolfs K, Wink J, Lessoud E, Vermat T, Cazals V, Silve S, Bauer A, Mourez M, Fraisse L, Leroi-Geissler C, Rey A, Versluys S, Bacqué E, Müller R, Renard S. Couturier C, et al. Among authors: bacque e. Angew Chem Int Ed Engl. 2022 Dec 19;61(51):e202210747. doi: 10.1002/anie.202210747. Epub 2022 Nov 21. Angew Chem Int Ed Engl. 2022. PMID: 36197755 Free PMC article.
Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions.
Gold B, Zhang J, Quezada LL, Roberts J, Ling Y, Wood M, Shinwari W, Goullieux L, Roubert C, Fraisse L, Bacqué E, Lagrange S, Filoche-Rommé B, Vieth M, Hipskind PA, Jungheim LN, Aubé J, Scarry SM, McDonald SL, Li K, Perkowski A, Nguyen Q, Dartois V, Zimmerman M, Olsen DB, Young K, Bonnett S, Joerss D, Parish T, Boshoff HI, Arora K, Barry CE 3rd, Guijarro L, Anca S, Rullas J, Rodríguez-Salguero B, Martínez-Martínez MS, Porras-De Francisco E, Cacho M, Barros-Aguirre D, Smith P, Berthel SJ, Nathan C, Bates RH. Gold B, et al. Among authors: bacque e. ACS Infect Dis. 2022 Mar 11;8(3):557-573. doi: 10.1021/acsinfecdis.1c00570. Epub 2022 Feb 22. ACS Infect Dis. 2022. PMID: 35192346 Free PMC article.
30 results