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Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
Tenesa A, Farrington SM, Prendergast JG, Porteous ME, Walker M, Haq N, Barnetson RA, Theodoratou E, Cetnarskyj R, Cartwright N, Semple C, Clark AJ, Reid FJ, Smith LA, Kavoussanakis K, Koessler T, Pharoah PD, Buch S, Schafmayer C, Tepel J, Schreiber S, Völzke H, Schmidt CO, Hampe J, Chang-Claude J, Hoffmeister M, Brenner H, Wilkening S, Canzian F, Capella G, Moreno V, Deary IJ, Starr JM, Tomlinson IP, Kemp Z, Howarth K, Carvajal-Carmona L, Webb E, Broderick P, Vijayakrishnan J, Houlston RS, Rennert G, Ballinger D, Rozek L, Gruber SB, Matsuda K, Kidokoro T, Nakamura Y, Zanke BW, Greenwood CM, Rangrej J, Kustra R, Montpetit A, Hudson TJ, Gallinger S, Campbell H, Dunlop MG. Tenesa A, et al. Among authors: walker m. Nat Genet. 2008 May;40(5):631-7. doi: 10.1038/ng.133. Epub 2008 Mar 30. Nat Genet. 2008. PMID: 18372901 Free PMC article.
Diet, environmental factors, and lifestyle underlie the high prevalence of vitamin D deficiency in healthy adults in Scotland, and supplementation reduces the proportion that are severely deficient.
Zgaga L, Theodoratou E, Farrington SM, Agakov F, Tenesa A, Walker M, Knox S, Wallace AM, Cetnarskyj R, McNeill G, Kyle J, Porteous ME, Dunlop MG, Campbell H. Zgaga L, et al. Among authors: walker m. J Nutr. 2011 Aug;141(8):1535-42. doi: 10.3945/jn.111.140012. Epub 2011 Jun 22. J Nutr. 2011. PMID: 21697298 Free PMC article.
TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres.
Jones AM, Beggs AD, Carvajal-Carmona L, Farrington S, Tenesa A, Walker M, Howarth K, Ballereau S, Hodgson SV, Zauber A, Bertagnolli M, Midgley R, Campbell H, Kerr D, Dunlop MG, Tomlinson IP. Jones AM, et al. Among authors: walker m. Gut. 2012 Feb;61(2):248-54. doi: 10.1136/gut.2011.239772. Epub 2011 Jun 27. Gut. 2012. PMID: 21708826 Free PMC article.
Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study.
He Y, Timofeeva M, Farrington SM, Vaughan-Shaw P, Svinti V, Walker M, Zgaga L, Meng X, Li X, Spiliopoulou A, Jiang X, Hyppönen E, Kraft P, Kiel DP; SUNLIGHT consortium; Hayward C, Campbell A, Porteous D, Vucic K, Kirac I, Filipovic M, Harris SE, Deary IJ, Houlston R, Tomlinson IP, Campbell H, Theodoratou E, Dunlop MG. He Y, et al. Among authors: walker m. BMC Med. 2018 Aug 14;16(1):142. doi: 10.1186/s12916-018-1119-2. BMC Med. 2018. PMID: 30103784 Free PMC article. Clinical Trial.
Low plasma vitamin D is associated with adverse colorectal cancer survival after surgical resection, independent of systemic inflammatory response.
Vaughan-Shaw PG, Zgaga L, Ooi LY, Theodoratou E, Timofeeva M, Svinti V, Walker M, O'Sullivan F, Ewing A, Johnston S, Din FVN, Campbell H, Farrington SM, Dunlop MG. Vaughan-Shaw PG, et al. Among authors: walker m. Gut. 2020 Jan;69(1):103-111. doi: 10.1136/gutjnl-2018-317922. Epub 2019 Apr 25. Gut. 2020. PMID: 31023832 Free PMC article.
Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study.
Zhang X, Theodoratou E, Li X, Farrington SM, Law PJ, Broderick P, Walker M, Klimentidis YC, Rees JMB, Houlston RS, Tomlinson IPM, Burgess S, Campbell H, Dunlop MG, Timofeeva M. Zhang X, et al. Among authors: walker m. Br J Cancer. 2021 Mar;124(7):1330-1338. doi: 10.1038/s41416-020-01236-2. Epub 2021 Jan 29. Br J Cancer. 2021. PMID: 33510439 Free PMC article.
7,099 results