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Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation.
Cordero-Espinoza L, Dowbaj AM, Kohler TN, Strauss B, Sarlidou O, Belenguer G, Pacini C, Martins NP, Dobie R, Wilson-Kanamori JR, Butler R, Prior N, Serup P, Jug F, Henderson NC, Hollfelder F, Huch M. Cordero-Espinoza L, et al. Among authors: henderson nc. Cell Stem Cell. 2021 Nov 4;28(11):1907-1921.e8. doi: 10.1016/j.stem.2021.07.002. Epub 2021 Aug 2. Cell Stem Cell. 2021. PMID: 34343491 Free PMC article.
A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.
Minutti CM, Modak RV, Macdonald F, Li F, Smyth DJ, Dorward DA, Blair N, Husovsky C, Muir A, Giampazolias E, Dobie R, Maizels RM, Kendall TJ, Griggs DW, Kopf M, Henderson NC, Zaiss DM. Minutti CM, et al. Among authors: henderson nc. Immunity. 2019 Mar 19;50(3):645-654.e6. doi: 10.1016/j.immuni.2019.01.008. Epub 2019 Feb 12. Immunity. 2019. PMID: 30770250 Free PMC article.
Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction.
Li Z, Solomonidis EG, Meloni M, Taylor RS, Duffin R, Dobie R, Magalhaes MS, Henderson BEP, Louwe PA, D'Amico G, Hodivala-Dilke KM, Shah AM, Mills NL, Simons BD, Gray GA, Henderson NC, Baker AH, Brittan M. Li Z, et al. Among authors: henderson nc, henderson bep. Eur Heart J. 2019 Aug 7;40(30):2507-2520. doi: 10.1093/eurheartj/ehz305. Eur Heart J. 2019. PMID: 31162546 Free PMC article.
Transcriptional dynamics of pluripotent stem cell-derived endothelial cell differentiation revealed by single-cell RNA sequencing.
McCracken IR, Taylor RS, Kok FO, de la Cuesta F, Dobie R, Henderson BEP, Mountford JC, Caudrillier A, Henderson NC, Ponting CP, Baker AH. McCracken IR, et al. Among authors: henderson nc, henderson bep. Eur Heart J. 2020 Mar 1;41(9):1024-1036. doi: 10.1093/eurheartj/ehz351. Eur Heart J. 2020. PMID: 31242503 Free PMC article.
Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy.
Sivertsen Åsrud K, Pedersen L, Aesoy R, Muwonge H, Aasebø E, Nitschke Pettersen IK, Herfindal L, Dobie R, Jenkins S, Berge RK, Henderson NC, Selheim F, Døskeland SO, Bakke M. Sivertsen Åsrud K, et al. Among authors: henderson nc. Sci Rep. 2019 Sep 24;9(1):13789. doi: 10.1038/s41598-019-50219-8. Sci Rep. 2019. PMID: 31551444 Free PMC article.
Resolving the fibrotic niche of human liver cirrhosis at single-cell level.
Ramachandran P, Dobie R, Wilson-Kanamori JR, Dora EF, Henderson BEP, Luu NT, Portman JR, Matchett KP, Brice M, Marwick JA, Taylor RS, Efremova M, Vento-Tormo R, Carragher NO, Kendall TJ, Fallowfield JA, Harrison EM, Mole DJ, Wigmore SJ, Newsome PN, Weston CJ, Iredale JP, Tacke F, Pollard JW, Ponting CP, Marioni JC, Teichmann SA, Henderson NC. Ramachandran P, et al. Among authors: henderson nc, henderson bep. Nature. 2019 Nov;575(7783):512-518. doi: 10.1038/s41586-019-1631-3. Epub 2019 Oct 9. Nature. 2019. PMID: 31597160 Free PMC article.
Unravelling fibrosis using single-cell transcriptomics.
Dobie R, Henderson NC. Dobie R, et al. Among authors: henderson nc. Curr Opin Pharmacol. 2019 Dec;49:71-75. doi: 10.1016/j.coph.2019.09.004. Epub 2019 Oct 25. Curr Opin Pharmacol. 2019. PMID: 31670054 Free article. Review.
Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis.
Dobie R, Wilson-Kanamori JR, Henderson BEP, Smith JR, Matchett KP, Portman JR, Wallenborg K, Picelli S, Zagorska A, Pendem SV, Hudson TE, Wu MM, Budas GR, Breckenridge DG, Harrison EM, Mole DJ, Wigmore SJ, Ramachandran P, Ponting CP, Teichmann SA, Marioni JC, Henderson NC. Dobie R, et al. Among authors: henderson nc, henderson bep. Cell Rep. 2019 Nov 12;29(7):1832-1847.e8. doi: 10.1016/j.celrep.2019.10.024. Cell Rep. 2019. PMID: 31722201 Free PMC article.
152 results