Yuan T - Search Results

1

Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods.

Yuan T, Yan N, Fei T, Zheng J, Meng J, Li N, Liu J, Zhang H, Xie L, Ying W, Li D, Shi L, Sun Y, Li Y, Li Y, Sun Y, Zuo E. Yuan T, et al. Nat Commun. 2021 Aug 12;12(1):4902. doi: 10.1038/s41467-021-25217-y. Nat Commun. 2021. PMID: 34385461 Free PMC article.

2

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.

Zuo E, Sun Y, Wei W, Yuan T, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H. Zuo E, et al. Among authors: yuan t, yuan l. Science. 2019 Apr 19;364(6437):289-292. doi: 10.1126/science.aav9973. Epub 2019 Feb 28. Science. 2019. PMID: 30819928 Free PMC article.

3

A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects.

Zuo E, Sun Y, Yuan T, He B, Zhou C, Ying W, Liu J, Wei W, Zeng R, Li Y, Yang H. Zuo E, et al. Among authors: yuan t. Nat Methods. 2020 Jun;17(6):600-604. doi: 10.1038/s41592-020-0832-x. Epub 2020 May 18. Nat Methods. 2020. PMID: 32424272

4

GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos.

Zuo E, Sun Y, Wei W, Yuan T, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H. Zuo E, et al. Among authors: yuan t, yuan l. Nat Protoc. 2020 Sep;15(9):3009-3029. doi: 10.1038/s41596-020-0361-1. Epub 2020 Aug 14. Nat Protoc. 2020. PMID: 32796939 Free PMC article.

5

Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects.

Lee S, Ding N, Sun Y, Yuan T, Li J, Yuan Q, Liu L, Yang J, Wang Q, Kolomeisky AB, Hilton IB, Zuo E, Gao X. Lee S, et al. Among authors: yuan q, yuan t. Sci Adv. 2020 Jul 15;6(29):eaba1773. doi: 10.1126/sciadv.aba1773. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32832622 Free PMC article.

6

Programmable RNA editing with compact CRISPR-Cas13 systems from uncultivated microbes.

Xu C, Zhou Y, Xiao Q, He B, Geng G, Wang Z, Cao B, Dong X, Bai W, Wang Y, Wang X, Zhou D, Yuan T, Huo X, Lai J, Yang H. Xu C, et al. Among authors: yuan t. Nat Methods. 2021 May;18(5):499-506. doi: 10.1038/s41592-021-01124-4. Epub 2021 May 3. Nat Methods. 2021. PMID: 33941935

7

Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice.

Yan N, Feng H, Sun Y, Xin Y, Zhang H, Lu H, Zheng J, He C, Zuo Z, Yuan T, Li N, Xie L, Wei W, Sun Y, Zuo E. Yan N, et al. Among authors: yuan t. Nat Commun. 2023 Mar 30;14(1):1784. doi: 10.1038/s41467-023-37508-7. Nat Commun. 2023. PMID: 36997536 Free PMC article.

8

Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes.

Yuan T, Wu L, Li S, Zheng J, Li N, Xiao X, Zhang H, Fei T, Xie L, Zuo Z, Li D, Huang P, Feng H, Cao Y, Yan N, Wei X, Shi L, Sun Y, Wei W, Sun Y, Zuo E. Yuan T, et al. Cell Discov. 2024 Feb 20;10(1):20. doi: 10.1038/s41421-023-00624-1. Cell Discov. 2024. PMID: 38378648 Free PMC article.

9

Undetectable off-target effects induced by FokI catalytic domain in mouse embryos.

Xie L, Feng H, Li Z, Li D, Yang X, Yuan T, Yan N, He C, Zheng J, Zuo Z, Zheng Y, Cao Y, Lu Y, Xiong XY, Zuo E. Xie L, et al. Among authors: yuan t. Genome Biol. 2024 Feb 20;25(1):51. doi: 10.1186/s13059-024-03188-9. Genome Biol. 2024. PMID: 38378658 Free PMC article.

10

Structure-guided discovery of highly efficient cytidine deaminases with sequence-context independence.

Xu K, Feng H, Zhang H, He C, Kang H, Yuan T, Shi L, Zhou C, Hua G, Cao Y, Zuo Z, Zuo E. Xu K, et al. Among authors: yuan t. Nat Biomed Eng. 2024 Jun 3. doi: 10.1038/s41551-024-01220-8. Online ahead of print. Nat Biomed Eng. 2024. PMID: 38831042

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