Brem J - Search Results

1

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis.

Rabe P, Kamps JJAG, Sutherlin KD, Linyard JDS, Aller P, Pham CC, Makita H, Clifton I, McDonough MA, Leissing TM, Shutin D, Lang PA, Butryn A, Brem J, Gul S, Fuller FD, Kim IS, Cheah MH, Fransson T, Bhowmick A, Young ID, O'Riordan L, Brewster AS, Pettinati I, Doyle M, Joti Y, Owada S, Tono K, Batyuk A, Hunter MS, Alonso-Mori R, Bergmann U, Owen RL, Sauter NK, Claridge TDW, Robinson CV, Yachandra VK, Yano J, Kern JF, Orville AM, Schofield CJ. Rabe P, et al. Among authors: brem j. Sci Adv. 2021 Aug 20;7(34):eabh0250. doi: 10.1126/sciadv.abh0250. Print 2021 Aug. Sci Adv. 2021. PMID: 34417180 Free PMC article.

2

Assay platform for clinically relevant metallo-β-lactamases.

van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. van Berkel SS, et al. Among authors: brem j. J Med Chem. 2013 Sep 12;56(17):6945-53. doi: 10.1021/jm400769b. Epub 2013 Aug 16. J Med Chem. 2013. PMID: 23898798 Free PMC article.

3

Binding of (5S)-penicilloic acid to penicillin binding protein 3.

van Berkel SS, Nettleship JE, Leung IK, Brem J, Choi H, Stuart DI, Claridge TD, McDonough MA, Owens RJ, Ren J, Schofield CJ. van Berkel SS, et al. Among authors: brem j. ACS Chem Biol. 2013 Oct 18;8(10):2112-6. doi: 10.1021/cb400200h. Epub 2013 Aug 15. ACS Chem Biol. 2013. PMID: 23899657

4

Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase.

Hamed RB, Henry L, Gomez-Castellanos JR, Asghar A, Brem J, Claridge TD, Schofield CJ. Hamed RB, et al. Among authors: brem j. Org Biomol Chem. 2013 Dec 21;11(47):8191-6. doi: 10.1039/c3ob41525b. Epub 2013 Oct 9. Org Biomol Chem. 2013. PMID: 24108359

5

Chromophore-linked substrate (CLS405): probing metallo-β-lactamase activity and inhibition.

Makena A, van Berkel SS, Lejeune C, Owens RJ, Verma A, Salimraj R, Spencer J, Brem J, Schofield CJ. Makena A, et al. Among authors: brem j. ChemMedChem. 2013 Dec;8(12):1923-9. doi: 10.1002/cmdc.201300350. Epub 2013 Oct 25. ChemMedChem. 2013. PMID: 24166830

6

Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy.

Rydzik AM, Brem J, van Berkel SS, Pfeffer I, Makena A, Claridge TD, Schofield CJ. Rydzik AM, et al. Among authors: brem j. Angew Chem Int Ed Engl. 2014 Mar 17;53(12):3129-33. doi: 10.1002/anie.201310866. Epub 2014 Feb 24. Angew Chem Int Ed Engl. 2014. PMID: 24615874 Free PMC article.

7

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.

Rydzik AM, Brem J, Struwe WB, Kochan GT, Benesch JL, Schofield CJ. Rydzik AM, et al. Among authors: brem j. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4954-7. doi: 10.1016/j.bmcl.2014.09.035. Epub 2014 Sep 19. Bioorg Med Chem Lett. 2014. PMID: 25266780

8

Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability.

Makena A, Brem J, Pfeffer I, Geffen RE, Wilkins SE, Tarhonskaya H, Flashman E, Phee LM, Wareham DW, Schofield CJ. Makena A, et al. Among authors: brem j. J Antimicrob Chemother. 2015 Feb;70(2):463-9. doi: 10.1093/jac/dku403. Epub 2014 Oct 16. J Antimicrob Chemother. 2015. PMID: 25324420 Free PMC article.

9

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition.

Brem J, van Berkel SS, Aik W, Rydzik AM, Avison MB, Pettinati I, Umland KD, Kawamura A, Spencer J, Claridge TD, McDonough MA, Schofield CJ. Brem J, et al. Nat Chem. 2014 Dec;6(12):1084-90. doi: 10.1038/nchem.2110. Epub 2014 Nov 17. Nat Chem. 2014. PMID: 25411887

10

Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.

Pettinati I, Brem J, McDonough MA, Schofield CJ. Pettinati I, et al. Among authors: brem j. Hum Mol Genet. 2015 May 1;24(9):2458-69. doi: 10.1093/hmg/ddv007. Epub 2015 Jan 16. Hum Mol Genet. 2015. PMID: 25596185 Free PMC article.

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