Ciulli A - Search Results

1

Mechanistic and Structural Features of PROTAC Ternary Complexes.

Casement R, Bond A, Craigon C, Ciulli A. Casement R, et al. Among authors: ciulli a. Methods Mol Biol. 2021;2365:79-113. doi: 10.1007/978-1-0716-1665-9_5. Methods Mol Biol. 2021. PMID: 34432240

2

Biophysical screening for the discovery of small-molecule ligands.

Ciulli A. Ciulli A. Methods Mol Biol. 2013;1008:357-88. doi: 10.1007/978-1-62703-398-5_13. Methods Mol Biol. 2013. PMID: 23729259 Free PMC article.

3

Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).

Bulatov E, Martin EM, Chatterjee S, Knebel A, Shimamura S, Konijnenberg A, Johnson C, Zinn N, Grandi P, Sobott F, Ciulli A. Bulatov E, et al. Among authors: ciulli a. J Biol Chem. 2015 Feb 13;290(7):4178-91. doi: 10.1074/jbc.M114.616664. Epub 2014 Dec 11. J Biol Chem. 2015. PMID: 25505247 Free PMC article.

4

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

Zengerle M, Chan KH, Ciulli A. Zengerle M, et al. Among authors: ciulli a. ACS Chem Biol. 2015 Aug 21;10(8):1770-7. doi: 10.1021/acschembio.5b00216. Epub 2015 Jun 16. ACS Chem Biol. 2015. PMID: 26035625 Free PMC article.

5

Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies.

Lucas X, Ciulli A. Lucas X, et al. Among authors: ciulli a. Curr Opin Struct Biol. 2017 Jun;44:101-110. doi: 10.1016/j.sbi.2016.12.015. Epub 2017 Jan 25. Curr Opin Struct Biol. 2017. PMID: 28130986 Review.

6

Structural basis of PROTAC cooperative recognition for selective protein degradation.

Gadd MS, Testa A, Lucas X, Chan KH, Chen W, Lamont DJ, Zengerle M, Ciulli A. Gadd MS, et al. Among authors: ciulli a. Nat Chem Biol. 2017 May;13(5):514-521. doi: 10.1038/nchembio.2329. Epub 2017 Mar 13. Nat Chem Biol. 2017. PMID: 28288108 Free PMC article.

7

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

Maniaci C, Hughes SJ, Testa A, Chen W, Lamont DJ, Rocha S, Alessi DR, Romeo R, Ciulli A. Maniaci C, et al. Among authors: ciulli a. Nat Commun. 2017 Oct 10;8(1):830. doi: 10.1038/s41467-017-00954-1. Nat Commun. 2017. PMID: 29018234 Free PMC article.

8

Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders.

Hughes SJ, Ciulli A. Hughes SJ, et al. Among authors: ciulli a. Essays Biochem. 2017 Nov 8;61(5):505-516. doi: 10.1042/EBC20170041. Print 2017 Nov 8. Essays Biochem. 2017. PMID: 29118097 Free PMC article. Review.

9

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate.

Roy MJ, Winkler S, Hughes SJ, Whitworth C, Galant M, Farnaby W, Rumpel K, Ciulli A. Roy MJ, et al. Among authors: ciulli a. ACS Chem Biol. 2019 Mar 15;14(3):361-368. doi: 10.1021/acschembio.9b00092. Epub 2019 Feb 22. ACS Chem Biol. 2019. PMID: 30721025 Free PMC article.

10

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs.

Girardini M, Maniaci C, Hughes SJ, Testa A, Ciulli A. Girardini M, et al. Among authors: ciulli a. Bioorg Med Chem. 2019 Jun 15;27(12):2466-2479. doi: 10.1016/j.bmc.2019.02.048. Epub 2019 Feb 22. Bioorg Med Chem. 2019. PMID: 30826187 Free PMC article.

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