McNerney ME - Search Results

1

Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms.

Imgruet MK, Lutze J, An N, Hu B, Khan S, Kurkewich J, Martinez TC, Wolfgeher D, Gurbuxani SK, Kron SJ, McNerney ME. Imgruet MK, et al. Among authors: mcnerney me. Blood. 2021 Sep 2;138(9):790-805. doi: 10.1182/blood.2020009195. Blood. 2021. PMID: 34473231 Free PMC article.

2

An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.

Godley LA, Cunningham J, Dolan ME, Huang RS, Gurbuxani S, McNerney ME, Larson RA, Leong H, Lussier Y, Onel K, Odenike O, Stock W, White KP, Le Beau MM. Godley LA, et al. Among authors: mcnerney me. Semin Oncol. 2011 Apr;38(2):215-24. doi: 10.1053/j.seminoncol.2011.01.003. Semin Oncol. 2011. PMID: 21421111 Free PMC article. Review.

3

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia.

McNerney ME, Brown CD, Wang X, Bartom ET, Karmakar S, Bandlamudi C, Yu S, Ko J, Sandall BP, Stricker T, Anastasi J, Grossman RL, Cunningham JM, Le Beau MM, White KP. McNerney ME, et al. Blood. 2013 Feb 7;121(6):975-83. doi: 10.1182/blood-2012-04-426965. Epub 2012 Dec 3. Blood. 2013. PMID: 23212519 Free PMC article.

4

The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q).

McNerney ME, Brown CD, Peterson AL, Banerjee M, Larson RA, Anastasi J, Le Beau MM, White KP. McNerney ME, et al. Br J Haematol. 2014 Aug;166(4):550-6. doi: 10.1111/bjh.12964. Epub 2014 Jun 13. Br J Haematol. 2014. PMID: 24931631 Free PMC article.

5

The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters.

Arthur RK, An N, Khan S, McNerney ME. Arthur RK, et al. Among authors: mcnerney me. Nucleic Acids Res. 2017 Jun 20;45(11):6350-6361. doi: 10.1093/nar/gkx218. Nucleic Acids Res. 2017. PMID: 28369554 Free PMC article.

6

Therapy-related myeloid neoplasms: when genetics and environment collide.

McNerney ME, Godley LA, Le Beau MM. McNerney ME, et al. Nat Rev Cancer. 2017 Aug 24;17(9):513-527. doi: 10.1038/nrc.2017.60. Nat Rev Cancer. 2017. PMID: 28835720 Free PMC article. Review.

7

Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS.

An N, Khan S, Imgruet MK, Gurbuxani SK, Konecki SN, Burgess MR, McNerney ME. An N, et al. Among authors: mcnerney me. Blood. 2018 Jun 14;131(24):2682-2697. doi: 10.1182/blood-2017-10-810028. Epub 2018 Mar 28. Blood. 2018. PMID: 29592892 Free PMC article.

8

A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia.

Cahill KE, Karimi YH, Karrison TG, Jain N, Green M, Weiner H, Fulton N, Kadri S, Godley LA, Artz AS, Liu H, Thirman MJ, Le Beau MM, McNerney ME, Segal J, Larson RA, Stock W, Odenike O. Cahill KE, et al. Among authors: mcnerney me. Blood Adv. 2020 Feb 25;4(4):599-606. doi: 10.1182/bloodadvances.2019000795. Blood Adv. 2020. PMID: 32074275 Free PMC article. Clinical Trial.

9

Cytotoxic Therapy-Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms.

Stoddart A, Wang J, Fernald AA, Davis EM, Johnson CR, Hu C, Cheng JX, McNerney ME, Le Beau MM. Stoddart A, et al. Among authors: mcnerney me. Blood Cancer Discov. 2020 Jul;1(1):32-47. doi: 10.1158/2643-3230.BCD-19-0028. Blood Cancer Discov. 2020. PMID: 32924016 Free PMC article.

10

Genomic studies controvert the existence of the CUX1 p75 isoform.

Krishnan M, Senagolage MD, Baeten JT, Wolfgeher DJ, Khan S, Kron SJ, McNerney ME. Krishnan M, et al. Among authors: mcnerney me. Sci Rep. 2022 Jan 7;12(1):151. doi: 10.1038/s41598-021-03930-4. Sci Rep. 2022. PMID: 34997000 Free PMC article.

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