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NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition.
Moore AM, Zhou L, Cui J, Li L, Wu N, Yu A, Poddar S, Liang K, Abt ER, Kim S, Ghukasyan R, Khachatourian N, Pagano K, Elliott I, Dann AM, Riahi R, Le T, Dawson DW, Radu CG, Donahue TR. Moore AM, et al. Among authors: liang k. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2012469118. doi: 10.1073/pnas.2012469118. Proc Natl Acad Sci U S A. 2021. PMID: 33597293 Free PMC article.
Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells.
Abt ER, Le TM, Dann AM, Capri JR, Poddar S, Lok V, Li L, Liang K, Creech AL, Rashid K, Kim W, Wu N, Cui J, Cho A, Lee HR, Rosser EW, Link JM, Czernin J, Wu TT, Damoiseaux R, Dawson DW, Donahue TR, Radu CG. Abt ER, et al. Among authors: liang k. Cell Rep. 2022 Jan 11;38(2):110236. doi: 10.1016/j.celrep.2021.110236. Cell Rep. 2022. PMID: 35021095 Free PMC article.
18F-FDG PET Visualizes Systemic STING Agonist-Induced Lymphocyte Activation in Preclinical Models.
Le TM, Lee HR, Abt ER, Rashid K, Creech AL, Liang K, Cui J, Cho A, Wei L, Labora A, Chan C, Sanchez E, Kriti K, Karin D, Li L, Wu N, Mona C, Carlucci G, Hugo W, Wu TT, Donahue TR, Czernin J, Radu CG. Le TM, et al. Among authors: liang k. J Nucl Med. 2023 Jan;64(1):117-123. doi: 10.2967/jnumed.122.264121. Epub 2022 Jun 23. J Nucl Med. 2023. PMID: 35738905 Free PMC article.
MEK Inhibition Sensitizes Pancreatic Cancer to STING Agonism by Tumor Cell-intrinsic Amplification of Type I IFN Signaling.
Ghukasyan R, Liang K, Chau K, Li L, Chan C, Abt ER, Le T, Park JY, Wu N, Premji A, Damoiseaux R, Luu T, Labora A, Rashid K, Link JM, Radu CG, Donahue TR. Ghukasyan R, et al. Among authors: liang k. Clin Cancer Res. 2023 Aug 15;29(16):3130-3141. doi: 10.1158/1078-0432.CCR-22-3322. Clin Cancer Res. 2023. PMID: 37195712 Free PMC article.
2,920 results