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STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [18F]FLT PET imaging.
Liang K, Abt ER, Le TM, Cho A, Dann AM, Cui J, Li L, Rashid K, Creech AL, Wei L, Ghukasyan R, Rosser EW, Wu N, Carlucci G, Czernin J, Donahue TR, Radu CG. Liang K, et al. Among authors: rosser ew. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2105390118. doi: 10.1073/pnas.2105390118. Proc Natl Acad Sci U S A. 2021. PMID: 34480004 Free PMC article.
Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.
Abt ER, Rosser EW, Durst MA, Lok V, Poddar S, Le TM, Cho A, Kim W, Wei L, Song J, Capri JR, Xu S, Wu N, Slavik R, Jung ME, Damoiseaux R, Czernin J, Donahue TR, Lavie A, Radu CG. Abt ER, et al. Among authors: rosser ew. Cell Chem Biol. 2020 Feb 20;27(2):197-205.e6. doi: 10.1016/j.chembiol.2019.10.012. Epub 2019 Nov 13. Cell Chem Biol. 2020. PMID: 31734178 Free PMC article.
Development and preclinical pharmacology of a novel dCK inhibitor, DI-87.
Poddar S, Capparelli EV, Rosser EW, Gipson RM, Wei L, Le T, Jung ME, Radu C, Nikanjam M. Poddar S, et al. Among authors: rosser ew. Biochem Pharmacol. 2020 Feb;172:113742. doi: 10.1016/j.bcp.2019.113742. Epub 2019 Dec 6. Biochem Pharmacol. 2020. PMID: 31812677 Free PMC article.
Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias.
Sun DL, Poddar S, Pan RD, Rosser EW, Abt ER, Van Valkenburgh J, Le TM, Lok V, Hernandez SP, Song J, Li J, Turlik A, Chen X, Cheng CA, Chen W, Mona CE, Stuparu AD, Vergnes L, Reue K, Damoiseaux R, Zink JI, Czernin J, Donahue TR, Houk KN, Jung ME, Radu CG. Sun DL, et al. Among authors: rosser ew. RSC Med Chem. 2020 Feb 24;11(3):392-410. doi: 10.1039/c9md00594c. eCollection 2020 Mar 1. RSC Med Chem. 2020. PMID: 33479645 Free PMC article.
Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells.
Abt ER, Le TM, Dann AM, Capri JR, Poddar S, Lok V, Li L, Liang K, Creech AL, Rashid K, Kim W, Wu N, Cui J, Cho A, Lee HR, Rosser EW, Link JM, Czernin J, Wu TT, Damoiseaux R, Dawson DW, Donahue TR, Radu CG. Abt ER, et al. Among authors: rosser ew. Cell Rep. 2022 Jan 11;38(2):110236. doi: 10.1016/j.celrep.2021.110236. Cell Rep. 2022. PMID: 35021095 Free PMC article.
Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity.
Abt ER, Rashid K, Le TM, Li S, Lee HR, Lok V, Li L, Creech AL, Labora AN, Mandl HK, Lam AK, Cho A, Rezek V, Wu N, Abril-Rodriguez G, Rosser EW, Mittelman SD, Hugo W, Mehrling T, Bantia S, Ribas A, Donahue TR, Crooks GM, Wu TT, Radu CG. Abt ER, et al. Among authors: rosser ew. J Clin Invest. 2022 Aug 15;132(16):e160852. doi: 10.1172/JCI160852. J Clin Invest. 2022. PMID: 35653193 Free PMC article.
Evaluating [225Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice.
Taddio MF, Doshi S, Masri M, Jeanjean P, Hikmat F, Gerlach A, Nyiranshuti L, Rosser EW, Schaue D, Besserer-Offroy E, Carlucci G, Radu CG, Czernin J, Lückerath K, Mona CE. Taddio MF, et al. Among authors: rosser ew. Eur J Nucl Med Mol Imaging. 2024 Nov;51(13):4026-4037. doi: 10.1007/s00259-024-06809-4. Epub 2024 Jul 15. Eur J Nucl Med Mol Imaging. 2024. PMID: 39008063 Free PMC article.
11 results