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Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication.
Scarpa M, Kapoor S, Tvedte ES, Doshi KA, Zou YS, Singh P, Lee JK, Chatterjee A, Ali MKM, Bromley RE, Hotopp JCD, Rassool FV, Baer MR. Scarpa M, et al. Among authors: singh p. Oncotarget. 2021 Aug 31;12(18):1763-1779. doi: 10.18632/oncotarget.28042. eCollection 2021 Aug 31. Oncotarget. 2021. PMID: 34504649 Free PMC article.
PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition-Dependent GSK-3β-Mediated c-Myc and Pim-1 Proteasomal Degradation.
Scarpa M, Singh P, Bailey CM, Lee JK, Kapoor S, Lapidus RG, Niyongere S, Sangodkar J, Wang Y, Perrotti D, Narla G, Baer MR. Scarpa M, et al. Among authors: singh p. Mol Cancer Ther. 2021 Apr;20(4):676-690. doi: 10.1158/1535-7163.MCT-20-0663. Epub 2021 Feb 10. Mol Cancer Ther. 2021. PMID: 33568357 Free PMC article.
Pim Kinase Inhibitors Increase Gilteritinib Cytotoxicity in FLT3-ITD Acute Myeloid Leukemia Through GSK-3β Activation and c-Myc and Mcl-1 Proteasomal Degradation.
Lee JK, Chatterjee A, Scarpa M, Bailey CM, Niyongere S, Singh P, Mustafa Ali MK, Kapoor S, Wang Y, Silvestri G, Baer MR. Lee JK, et al. Among authors: singh p. Cancer Res Commun. 2024 Feb 16;4(2):431-445. doi: 10.1158/2767-9764.CRC-23-0379. Cancer Res Commun. 2024. PMID: 38284896 Free PMC article.
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