Chapman TM - Search Results

1

Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists.

Maciuszek M, Ortega-Gomez A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF, Soehnlein O, Chapman TM. Maciuszek M, et al. Among authors: chapman tm. Eur J Med Chem. 2021 Dec 15;226:113805. doi: 10.1016/j.ejmech.2021.113805. Epub 2021 Sep 2. Eur J Med Chem. 2021. PMID: 34536667 Free article.

2

Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential.

Maciuszek M, Cacace A, Brennan E, Godson C, Chapman TM. Maciuszek M, et al. Among authors: chapman tm. Eur J Med Chem. 2021 Mar 5;213:113167. doi: 10.1016/j.ejmech.2021.113167. Epub 2021 Jan 12. Eur J Med Chem. 2021. PMID: 33486199 Free article. Review.

3

Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation.

Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O, Chapman TM. Maciuszek M, et al. Among authors: chapman tm. Eur J Med Chem. 2021 Mar 15;214:113194. doi: 10.1016/j.ejmech.2021.113194. Epub 2021 Jan 16. Eur J Med Chem. 2021. PMID: 33548634 Free article.

4

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform.

Pant SM, Mukonoweshuro A, Desai B, Ramjee MK, Selway CN, Tarver GJ, Wright AG, Birchall K, Chapman TM, Tervonen TA, Klefström J. Pant SM, et al. Among authors: chapman tm. J Med Chem. 2018 May 24;61(10):4335-4347. doi: 10.1021/acs.jmedchem.7b01698. Epub 2018 May 14. J Med Chem. 2018. PMID: 29701962

5

Fragment-based hit identification: thinking in 3D.

Morley AD, Pugliese A, Birchall K, Bower J, Brennan P, Brown N, Chapman T, Drysdale M, Gilbert IH, Hoelder S, Jordan A, Ley SV, Merritt A, Miller D, Swarbrick ME, Wyatt PG. Morley AD, et al. Drug Discov Today. 2013 Dec;18(23-24):1221-7. doi: 10.1016/j.drudis.2013.07.011. Epub 2013 Jul 30. Drug Discov Today. 2013. PMID: 23906694 Review.

6

Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).

Chapman TM, Osborne SA, Wallace C, Birchall K, Bouloc N, Jones HM, Ansell KH, Taylor DL, Clough B, Green JL, Holder AA. Chapman TM, et al. J Med Chem. 2014 Apr 24;57(8):3570-87. doi: 10.1021/jm500342d. Epub 2014 Apr 11. J Med Chem. 2014. PMID: 24689770 Free PMC article.

7

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.

Chapman TM, Gillen KJ, Wallace C, Lee MT, Bakrania P, Khurana P, Coombs PJ, Stennett L, Fox S, Bureau EA, Brownlees J, Melton DW, Saxty B. Chapman TM, et al. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103. doi: 10.1016/j.bmcl.2015.08.031. Epub 2015 Aug 17. Bioorg Med Chem Lett. 2015. PMID: 26318993

8

Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).

Chapman TM, Osborne SA, Bouloc N, Large JM, Wallace C, Birchall K, Ansell KH, Jones HM, Taylor D, Clough B, Green JL, Holder AA. Chapman TM, et al. Bioorg Med Chem Lett. 2013 May 15;23(10):3064-9. doi: 10.1016/j.bmcl.2013.03.017. Epub 2013 Mar 21. Bioorg Med Chem Lett. 2013. PMID: 23570789 Free PMC article.

9

N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.

Chapman TM, Wallace C, Gillen KJ, Bakrania P, Khurana P, Coombs PJ, Fox S, Bureau EA, Brownlees J, Melton DW, Saxty B. Chapman TM, et al. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4104-8. doi: 10.1016/j.bmcl.2015.08.024. Epub 2015 Aug 14. Bioorg Med Chem Lett. 2015. PMID: 26321360

10

Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis.

Chapman TM, Bouloc N, Buxton RS, Chugh J, Lougheed KE, Osborne SA, Saxty B, Smerdon SJ, Taylor DL, Whalley D. Chapman TM, et al. Bioorg Med Chem Lett. 2012 May 1;22(9):3349-53. doi: 10.1016/j.bmcl.2012.02.107. Epub 2012 Mar 14. Bioorg Med Chem Lett. 2012. PMID: 22469702 Free PMC article.

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