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Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors.
Wang Z, Kang D, Chen M, Wu G, Feng D, Zhao T, Zhou Z, Huo Z, Jing L, Zuo X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Wang Z, et al. Among authors: feng d. Chem Biol Drug Des. 2018 Dec;92(6):2009-2021. doi: 10.1111/cbdd.13373. Epub 2018 Aug 26. Chem Biol Drug Des. 2018. PMID: 30079476
Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.
Kang D, Zhang H, Wang Z, Zhao T, Ginex T, Luque FJ, Yang Y, Wu G, Feng D, Wei F, Zhang J, De Clercq E, Pannecouque C, Chen CH, Lee KH, Murugan NA, Steitz TA, Zhan P, Liu X. Kang D, et al. Among authors: feng d. J Med Chem. 2019 Feb 14;62(3):1484-1501. doi: 10.1021/acs.jmedchem.8b01656. Epub 2019 Jan 18. J Med Chem. 2019. PMID: 30624934 Free PMC article.
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.
Kang D, Ruiz FX, Feng D, Pilch A, Zhao T, Wei F, Wang Z, Sun Y, Fang Z, De Clercq E, Pannecouque C, Arnold E, Liu X, Zhan P. Kang D, et al. Among authors: feng d. J Med Chem. 2020 Feb 13;63(3):1298-1312. doi: 10.1021/acs.jmedchem.9b01769. Epub 2020 Jan 24. J Med Chem. 2020. PMID: 31935327 Free PMC article.
Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs.
Kang D, Feng D, Ginex T, Zou J, Wei F, Zhao T, Huang B, Sun Y, Desta S, De Clercq E, Pannecouque C, Zhan P, Liu X. Kang D, et al. Among authors: feng d. Acta Pharm Sin B. 2020 May;10(5):878-894. doi: 10.1016/j.apsb.2019.08.013. Epub 2019 Sep 14. Acta Pharm Sin B. 2020. PMID: 32528834 Free PMC article.
4,341 results