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Page 1
Nicorandil antiallodynic activity in a model of neuropathic pain is associated with the activation of ATP-dependent potassium channels and opioidergic pathways, and reduced production of cytokines and neutrophils recruitment in paw, sciatic nerve, and dorsal root ganglia.
Braga AV, Morais MÍ, Delfino DGS, Costa SOAM, Barbosa BCM, Rodrigues FF, Melo ISF, Matos RC, Castro BFM, Cunha Júnior AS, Braga TC, de Fátima Â, Coelho MM, Machado RR. Braga AV, et al. Among authors: melo isf. Pharmacol Rep. 2024 Oct;76(5):1067-1078. doi: 10.1007/s43440-024-00640-2. Epub 2024 Aug 23. Pharmacol Rep. 2024. PMID: 39179890
Metformin inhibits paclitaxel-induced mechanical allodynia by activating opioidergic pathways and reducing cytokines production in the dorsal root ganglia and thalamus.
Morais MÍ, Braga AV, Silva RRL, Barbosa BCM, Costa SOAM, Rodrigues FF, Melo ISF, Matos RC, Carobin NV, Sabino AP, Coelho MM, Machado RR. Morais MÍ, et al. Among authors: melo isf. Cytokine. 2024 Feb;174:156468. doi: 10.1016/j.cyto.2023.156468. Epub 2023 Dec 14. Cytokine. 2024. PMID: 38101167 Free article.
A clindamycin acetylated derivative with reduced antibacterial activity inhibits articular hyperalgesia and edema by attenuating neutrophil recruitment, NF-κB activation and tumor necrosis factor-α production.
Rodrigues FF, Lino CI, Oliveira VLS, Zaidan I, Melo ISF, Braga AV, Costa SOAM, Morais MI, Barbosa BCM, da Costa YFG, Moreira NF, Alves MS, Braga AD, Carneiro FS, Carvalho AFS, Queiroz-Junior CM, Sousa LP, Amaral FA, Oliveira RB, Coelho MM, Machado RR. Rodrigues FF, et al. Among authors: melo isf. Int Immunopharmacol. 2023 Sep;122:110609. doi: 10.1016/j.intimp.2023.110609. Epub 2023 Jul 8. Int Immunopharmacol. 2023. PMID: 37429145 Free article.
Synthesis of 2-(2-(4-thioxo-3H-1,2-dithiole-5-yl) phenoxy)ethyl)isoindole-1,3-thione, a novel hydrogen sulfide-releasing phthalimide hybrid, and evaluation of its activity in models of inflammatory pain.
Melo ISF, Ziviani VP, Barbosa BCM, Rodrigues FF, Silva RRL, da Silva Neto L, de Fátima Â, César IC, Machado RR, Coelho MM. Melo ISF, et al. Eur J Pharmacol. 2023 Jan 5;938:175409. doi: 10.1016/j.ejphar.2022.175409. Epub 2022 Nov 25. Eur J Pharmacol. 2023. PMID: 36436591
RI75, a curcumin analogue, inhibits tumor necrosis factor-α and interleukin-6 production and exhibits antiallodynic and antiedematogenic activities in mice.
Costa SOAM, Rodrigues IB, Braga AV, Barbosa BCM, Silva RRL, Rodrigues FF, Melo ISF, Morais MÍ, Castro BFM, Júnior ASC, Maltarollo VG, Oliveira RB, Coelho MM, Machado RR. Costa SOAM, et al. Among authors: melo isf. Inflammopharmacology. 2022 Apr;30(2):505-515. doi: 10.1007/s10787-021-00913-9. Epub 2022 Jan 30. Inflammopharmacology. 2022. PMID: 35094257
Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production.
Augusto PSA, Matsui TC, Braga AV, Rodrigues FF, Morais MI, Dutra MMGB, Batista CRA, Melo ISF, Costa SOAM, Bertollo CM, Coelho MM, Machado RR. Augusto PSA, et al. Among authors: melo isf. Inflammopharmacology. 2022 Feb;30(1):233-241. doi: 10.1007/s10787-021-00899-4. Epub 2021 Nov 30. Inflammopharmacology. 2022. PMID: 34850313
Chenopodin as an anti-inflammatory compound.
Pompeu DG, Cordeiro HG, Tonelli FCP, Godin AM, Melo ISF, Matsui TC, Rodrigues FF, Silva JAD, Coelho MM, Machado RR, Granjeiro PA. Pompeu DG, et al. Among authors: melo isf. Nat Prod Res. 2022 Sep;36(17):4435-4438. doi: 10.1080/14786419.2021.1980791. Epub 2021 Sep 21. Nat Prod Res. 2022. PMID: 34544288
Electrochemical evidence of nitrate release from the nitrooxy compound 4-((nitrooxy) methyl)-3-nitrobenzoic acid and its antinociceptive and anti-inflammatory activities in mice.
Braga AV, da Silva RRL, Rodrigues IB, Marques GVL, Xavier AFA, Boane A, Paiva MRB, Franco PHC, Rodrigues FF, Melo ISF, Silva Cunha Júnior AD, César IDC, Goulart MOF, Oliveira RB, Coelho MM, Machado RR. Braga AV, et al. Among authors: melo isf. Biomed Pharmacother. 2021 Jan;133:110913. doi: 10.1016/j.biopha.2020.110913. Epub 2020 Nov 27. Biomed Pharmacother. 2021. PMID: 33249284 Free article.
The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain.
Batista CRA, Godin AM, Melo ISF, Coura GME, Matsui TC, Dutra MMGB, Brito AMS, Canhestro WG, Alves RJ, Araújo DP, de Fátima Â, Machado RR, Coelho MM. Batista CRA, et al. Among authors: melo isf. Pharmacol Rep. 2019 Dec;71(6):1177-1183. doi: 10.1016/j.pharep.2019.08.001. Epub 2019 Aug 17. Pharmacol Rep. 2019. PMID: 31669881
23 results