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Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study.
Cusi K, Alkhouri N, Harrison SA, Fouqueray P, Moller DE, Hallakou-Bozec S, Bolze S, Grouin JM, Jeannin Megnien S, Dubourg J, Ratziu V. Cusi K, et al. Among authors: grouin jm. Lancet Gastroenterol Hepatol. 2021 Nov;6(11):889-902. doi: 10.1016/S2468-1253(21)00300-9. Epub 2021 Sep 22. Lancet Gastroenterol Hepatol. 2021. PMID: 34560015 Clinical Trial.
Long-term safety and efficacy of imeglimin as monotherapy or in combination with existing antidiabetic agents in Japanese patients with type 2 diabetes (TIMES 2): A 52-week, open-label, multicentre phase 3 trial.
Dubourg J, Fouqueray P, Quinslot D, Grouin JM, Kaku K. Dubourg J, et al. Among authors: grouin jm. Diabetes Obes Metab. 2022 Apr;24(4):609-619. doi: 10.1111/dom.14613. Epub 2021 Dec 27. Diabetes Obes Metab. 2022. PMID: 34866306 Free PMC article. Clinical Trial.
Efficacy and safety of imeglimin add-on to insulin monotherapy in Japanese patients with type 2 diabetes (TIMES 3): A randomized, double-blind, placebo-controlled phase 3 trial with a 36-week open-label extension period.
Reilhac C, Dubourg J, Thang C, Grouin JM, Fouqueray P, Watada H. Reilhac C, et al. Among authors: grouin jm. Diabetes Obes Metab. 2022 May;24(5):838-848. doi: 10.1111/dom.14642. Epub 2022 Feb 8. Diabetes Obes Metab. 2022. PMID: 34984815 Free PMC article. Clinical Trial.
Pharmacodynamic effects of direct AMP kinase activation in humans with insulin resistance and non-alcoholic fatty liver disease: A phase 1b study.
Fouqueray P, Bolze S, Dubourg J, Hallakou-Bozec S, Theurey P, Grouin JM, Chevalier C, Gluais-Dagorn P, Moller DE, Cusi K. Fouqueray P, et al. Among authors: grouin jm. Cell Rep Med. 2021 Dec 21;2(12):100474. doi: 10.1016/j.xcrm.2021.100474. eCollection 2021 Dec 21. Cell Rep Med. 2021. PMID: 35028615 Free PMC article. Clinical Trial.
Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial.
François B, Lambden S, Fivez T, Gibot S, Derive M, Grouin JM, Salcedo-Magguilli M, Lemarié J, De Schryver N, Jalkanen V, Hicheur T, Garaud JJ, Cuvier V, Ferrer R, Bestle M, Pettilä V, Mira JP, Bouisse C, Mercier E, Vermassen J, Huberlant V, Vinatier I, Anguel N, Levy M, Laterre PF; ASTONISH investigators. François B, et al. Among authors: grouin jm. Lancet Respir Med. 2023 Oct;11(10):894-904. doi: 10.1016/S2213-2600(23)00158-3. Epub 2023 May 31. Lancet Respir Med. 2023. PMID: 37269870 Clinical Trial.
Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect.
Maheu E, Mazières B, Valat JP, Loyau G, Le Loët X, Bourgeois P, Grouin JM, Rozenberg S. Maheu E, et al. Among authors: grouin jm. Arthritis Rheum. 1998 Jan;41(1):81-91. doi: 10.1002/1529-0131(199801)41:1<81::AID-ART11>3.0.CO;2-9. Arthritis Rheum. 1998. PMID: 9433873 Clinical Trial.
Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study.
Maheu E, Cadet C, Marty M, Moyse D, Kerloch I, Coste P, Dougados M, Mazières B, Spector TD, Halhol H, Grouin JM, Lequesne M. Maheu E, et al. Among authors: grouin jm. Ann Rheum Dis. 2014 Feb;73(2):376-84. doi: 10.1136/annrheumdis-2012-202485. Epub 2013 Jan 23. Ann Rheum Dis. 2014. PMID: 23345601 Free PMC article. Clinical Trial.
IqYmune® is an effective maintenance treatment for multifocal motor neuropathy: A randomised, double-blind, multi-center cross-over non-inferiority study vs Kiovig®-The LIME Study.
Léger JM, Alfa Cissé O, Cocito D, Grouin JM, Katifi H, Nobile-Orazio E, Ouaja R, Pouget J, Rajabally YA, Sevilla T, Merkies ISJ. Léger JM, et al. Among authors: grouin jm. J Peripher Nerv Syst. 2019 Mar;24(1):56-63. doi: 10.1111/jns.12291. Epub 2018 Dec 11. J Peripher Nerv Syst. 2019. PMID: 30456899 Free PMC article. Clinical Trial.
47 results