Jo U - Search Results

1

Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11.

Jo U, Murai Y, Takebe N, Thomas A, Pommier Y. Jo U, et al. Cancers (Basel). 2021 Sep 14;13(18):4601. doi: 10.3390/cancers13184601. Cancers (Basel). 2021. PMID: 34572827 Free PMC article. Review.

2

Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress.

Murai J, Zhang H, Pongor L, Tang SW, Jo U, Moribe F, Ma Y, Tomita M, Pommier Y. Murai J, et al. Among authors: jo u. Cell Rep. 2020 Mar 24;30(12):4137-4151.e6. doi: 10.1016/j.celrep.2020.02.117. Cell Rep. 2020. PMID: 32209474 Free PMC article.

3

Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways.

Sun Y, Saha LK, Saha S, Jo U, Pommier Y. Sun Y, et al. Among authors: jo u. DNA Repair (Amst). 2020 Oct;94:102926. doi: 10.1016/j.dnarep.2020.102926. Epub 2020 Jul 10. DNA Repair (Amst). 2020. PMID: 32674013 Free PMC article. Review.

4

DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks.

Saha S, Sun Y, Huang SN, Baechler SA, Pongor LS, Agama K, Jo U, Zhang H, Tse-Dinh YC, Pommier Y. Saha S, et al. Among authors: jo u. Cell Rep. 2020 Dec 29;33(13):108569. doi: 10.1016/j.celrep.2020.108569. Cell Rep. 2020. PMID: 33378676 Free PMC article.

5

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

Jo U, Murai Y, Chakka S, Chen L, Cheng K, Murai J, Saha LK, Miller Jenkins LM, Pommier Y. Jo U, et al. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2015654118. doi: 10.1073/pnas.2015654118. Proc Natl Acad Sci U S A. 2021. PMID: 33536335 Free PMC article.

6

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.

Murai Y, Jo U, Murai J, Jenkins LM, Huang SN, Chakka S, Chen L, Cheng K, Fukuda S, Takebe N, Pommier Y. Murai Y, et al. Among authors: jo u. Cancer Res. 2021 Jun 1;81(11):3067-3078. doi: 10.1158/0008-5472.CAN-20-2694. Epub 2021 Apr 16. Cancer Res. 2021. PMID: 33863777 Free PMC article.

7

Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents.

Jo U, Senatorov IS, Zimmermann A, Saha LK, Murai Y, Kim SH, Rajapakse VN, Elloumi F, Takahashi N, Schultz CW, Thomas A, Zenke FT, Pommier Y. Jo U, et al. Mol Cancer Ther. 2021 Aug;20(8):1431-1441. doi: 10.1158/1535-7163.MCT-20-1026. Epub 2021 May 27. Mol Cancer Ther. 2021. PMID: 34045232 Free PMC article.

8

Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes.

Saha LK, Murai Y, Saha S, Jo U, Tsuda M, Takeda S, Pommier Y. Saha LK, et al. Among authors: jo u. Nucleic Acids Res. 2021 Oct 11;49(18):10493-10506. doi: 10.1093/nar/gkab777. Nucleic Acids Res. 2021. PMID: 34551432 Free PMC article.

9

Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway.

Murai Y, Jo U, Murai J, Fukuda S, Takebe N, Pommier Y. Murai Y, et al. Among authors: jo u. iScience. 2021 Sep 25;24(10):103173. doi: 10.1016/j.isci.2021.103173. eCollection 2021 Oct 22. iScience. 2021. PMID: 34693224 Free PMC article.

10

TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor.

Jo U, Murai Y, Agama KK, Sun Y, Saha LK, Yang X, Arakawa Y, Gayle S, Jones K, Paralkar V, Sundaram RK, Van Doorn J, Vasquez JC, Bindra RS, Choi WS, Pommier Y. Jo U, et al. Mol Cancer Ther. 2022 Jul 5;21(7):1090-1102. doi: 10.1158/1535-7163.MCT-21-1000. Mol Cancer Ther. 2022. PMID: 35439320 Free PMC article.

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