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A prenylated dsRNA sensor protects against severe COVID-19.
Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull ML, Loney C, Herder V, Allan J, Jarmson I, Cameron-Ruiz N, Varjak M, Pinto RM, Lee JY, Iselin L, Palmalux N, Stewart DG, Swingler S, Greenwood EJD, Crozier TWM, Gu Q, Davies EL, Clohisey S, Wang B, Trindade Maranhão Costa F, Freire Santana M, de Lima Ferreira LC, Murphy L, Fawkes A, Meynert A, Grimes G; ISARIC4C Investigators; Da Silva Filho JL, Marti M, Hughes J, Stanton RJ, Wang ECY, Ho A, Davis I, Jarrett RF, Castello A, Robertson DL, Semple MG, Openshaw PJM, Palmarini M, Lehner PJ, Baillie JK, Rihn SJ, Wilson SJ. Wickenhagen A, et al. Among authors: gu q. Science. 2021 Oct 29;374(6567):eabj3624. doi: 10.1126/science.abj3624. Epub 2021 Oct 29. Science. 2021. PMID: 34581622 Free PMC article.
The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting.
Shaw AE, Rihn SJ, Mollentze N, Wickenhagen A, Stewart DG, Orton RJ, Kuchi S, Bakshi S, Collados MR, Turnbull ML, Busby J, Gu Q, Smollett K, Bamford CGG, Sugrue E, Johnson PCD, Da Silva AF, Castello A, Streicker DG, Robertson DL, Palmarini M, Wilson SJ. Shaw AE, et al. Among authors: gu q. PLoS Biol. 2021 Sep 7;19(9):e3001352. doi: 10.1371/journal.pbio.3001352. eCollection 2021 Sep. PLoS Biol. 2021. PMID: 34491982 Free PMC article.
Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defenses.
Herder V, Dee K, Wojtus JK, Epifano I, Goldfarb D, Rozario C, Gu Q, Da Silva Filipe A, Nomikou K, Nichols J, Jarrett RF, Stevenson A, McFarlane S, Stewart ME, Szemiel AM, Pinto RM, Masdefiol Garriga A, Davis C, Allan J, Graham SV, Murcia PR, Boutell C. Herder V, et al. Among authors: gu q. PLoS Biol. 2021 Dec 21;19(12):e3001065. doi: 10.1371/journal.pbio.3001065. eCollection 2021 Dec. PLoS Biol. 2021. PMID: 34932557 Free PMC article.
3,734 results