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Page 1
A prenylated dsRNA sensor protects against severe COVID-19.
Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull ML, Loney C, Herder V, Allan J, Jarmson I, Cameron-Ruiz N, Varjak M, Pinto RM, Lee JY, Iselin L, Palmalux N, Stewart DG, Swingler S, Greenwood EJD, Crozier TWM, Gu Q, Davies EL, Clohisey S, Wang B, Trindade Maranhão Costa F, Freire Santana M, de Lima Ferreira LC, Murphy L, Fawkes A, Meynert A, Grimes G; ISARIC4C Investigators; Da Silva Filho JL, Marti M, Hughes J, Stanton RJ, Wang ECY, Ho A, Davis I, Jarrett RF, Castello A, Robertson DL, Semple MG, Openshaw PJM, Palmarini M, Lehner PJ, Baillie JK, Rihn SJ, Wilson SJ. Wickenhagen A, et al. Among authors: iselin l. Science. 2021 Oct 29;374(6567):eabj3624. doi: 10.1126/science.abj3624. Epub 2021 Oct 29. Science. 2021. PMID: 34581622 Free PMC article.
Uncovering viral RNA-host cell interactions on a proteome-wide scale.
Iselin L, Palmalux N, Kamel W, Simmonds P, Mohammed S, Castello A. Iselin L, et al. Trends Biochem Sci. 2022 Jan;47(1):23-38. doi: 10.1016/j.tibs.2021.08.002. Epub 2021 Sep 9. Trends Biochem Sci. 2022. PMID: 34509361 Free PMC article. Review.
Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences.
Lee JY, Wing PAC, Gala DS, Noerenberg M, Järvelin AI, Titlow J, Zhuang X, Palmalux N, Iselin L, Thompson MK, Parton RM, Prange-Barczynska M, Wainman A, Salguero FJ, Bishop T, Agranoff D, James W, Castello A, McKeating JA, Davis I. Lee JY, et al. Among authors: iselin l. Elife. 2022 Jan 20;11:e74153. doi: 10.7554/eLife.74153. Elife. 2022. PMID: 35049501 Free PMC article.
The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity.
Álvarez L, Haubrich K, Iselin L, Gillioz L, Ruscica V, Lapouge K, Augsten S, Huppertz I, Choudhury NR, Simon B, Masiewicz P, Lethier M, Cusack S, Rittinger K, Gabel F, Leitner A, Michlewski G, Hentze MW, Allain FHT, Castello A, Hennig J. Álvarez L, et al. Among authors: iselin l. Nat Commun. 2024 Oct 1;15(1):8485. doi: 10.1038/s41467-024-52918-x. Nat Commun. 2024. PMID: 39353916 Free PMC article.
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles.
Kamel W, Ruscica V, Embarc-Buh A, de Laurent ZR, Garcia-Moreno M, Demyanenko Y, Orton RJ, Noerenberg M, Madhusudhan M, Iselin L, Järvelin AI, Hannan M, Kitano E, Moore S, Merits A, Davis I, Mohammed S, Castello A. Kamel W, et al. Among authors: iselin l. Mol Cell. 2024 Dec 19;84(24):4896-4911.e7. doi: 10.1016/j.molcel.2024.11.015. Epub 2024 Dec 11. Mol Cell. 2024. PMID: 39642884 Free article.
Presenting technological workflows.
Sánchez MF, Iselin L, Simonetti L. Sánchez MF, et al. Among authors: iselin l. Trends Biochem Sci. 2023 Jul;48(7):587-589. doi: 10.1016/j.tibs.2023.04.001. Trends Biochem Sci. 2023. PMID: 37295391 No abstract available.
41 results