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Page 1
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases.
Robinson PS, Coorens THH, Palles C, Mitchell E, Abascal F, Olafsson S, Lee BCH, Lawson ARJ, Lee-Six H, Moore L, Sanders MA, Hewinson J, Martin L, Pinna CMA, Galavotti S, Rahbari R, Campbell PJ, Martincorena I, Tomlinson I, Stratton MR. Robinson PS, et al. Among authors: lee bch. Nat Genet. 2021 Oct;53(10):1434-1442. doi: 10.1038/s41588-021-00930-y. Epub 2021 Sep 30. Nat Genet. 2021. PMID: 34594041 Free PMC article.
Mutational landscape of normal epithelial cells in Lynch Syndrome patients.
Lee BCH, Robinson PS, Coorens THH, Yan HHN, Olafsson S, Lee-Six H, Sanders MA, Siu HC, Hewinson J, Yue SSK, Tsui WY, Chan ASY, Chan AKW, Ho SL, Campbell PJ, Martincorena I, Buczacki SJA, Yuen ST, Leung SY, Stratton MR. Lee BCH, et al. Nat Commun. 2022 May 17;13(1):2710. doi: 10.1038/s41467-022-29920-2. Nat Commun. 2022. PMID: 35581206 Free PMC article.
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.
Robinson PS, Thomas LE, Abascal F, Jung H, Harvey LMR, West HD, Olafsson S, Lee BCH, Coorens THH, Lee-Six H, Butlin L, Lander N, Truscott R, Sanders MA, Lensing SV, Buczacki SJA, Ten Hoopen R, Coleman N, Brunton-Sim R, Rushbrook S, Saeb-Parsy K, Lalloo F, Campbell PJ, Martincorena I, Sampson JR, Stratton MR. Robinson PS, et al. Among authors: lee bch. Nat Commun. 2022 Jul 8;13(1):3949. doi: 10.1038/s41467-022-31341-0. Nat Commun. 2022. PMID: 35803914 Free PMC article.
A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.
Yan HHN, Siu HC, Law S, Ho SL, Yue SSK, Tsui WY, Chan D, Chan AS, Ma S, Lam KO, Bartfeld S, Man AHY, Lee BCH, Chan ASY, Wong JWH, Cheng PSW, Chan AKW, Zhang J, Shi J, Fan X, Kwong DLW, Mak TW, Yuen ST, Clevers H, Leung SY. Yan HHN, et al. Among authors: lee bch. Cell Stem Cell. 2018 Dec 6;23(6):882-897.e11. doi: 10.1016/j.stem.2018.09.016. Epub 2018 Oct 18. Cell Stem Cell. 2018. PMID: 30344100 Free article.
Accuracy of Implant Analogs in 3D Printed Resin Models.
Maria R, Tan MY, Wong KM, Lee BCH, Chia VAP, Tan KBC. Maria R, et al. Among authors: lee bch. J Prosthodont. 2021 Jan;30(1):57-64. doi: 10.1111/jopr.13217. Epub 2020 Jul 2. J Prosthodont. 2021. PMID: 32567126
Epigenetic regulation of centromere function.
Wong CYY, Lee BCH, Yuen KWY. Wong CYY, et al. Among authors: lee bch. Cell Mol Life Sci. 2020 Aug;77(15):2899-2917. doi: 10.1007/s00018-020-03460-8. Epub 2020 Feb 1. Cell Mol Life Sci. 2020. PMID: 32008088 Free PMC article. Review.