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[O-methyl-11C]N-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1H-indole-2-carboxamide ([11C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D₃ Receptors in Rodents and Monkey.
Liow JS, Morse CL, Lu S, Frankland M, Tye GL, Zoghbi SS, Gladding RL, Shaik AB, Innis RB, Newman AH, Pike VW. Liow JS, et al. Among authors: shaik ab. Molecules. 2018 Oct 23;23(11):2737. doi: 10.3390/molecules23112737. Molecules. 2018. PMID: 30360553 Free PMC article.
Investigation of Novel Primary and Secondary Pharmacophores and 3-Substitution in the Linking Chain of a Series of Highly Selective and Bitopic Dopamine D3 Receptor Antagonists and Partial Agonists.
Shaik AB, Kumar V, Bonifazi A, Guerrero AM, Cemaj SL, Gadiano A, Lam J, Xi ZX, Rais R, Slusher BS, Newman AH. Shaik AB, et al. J Med Chem. 2019 Oct 24;62(20):9061-9077. doi: 10.1021/acs.jmedchem.9b00607. Epub 2019 Oct 15. J Med Chem. 2019. PMID: 31526003 Free PMC article.
Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.
Bonifazi A, Battiti FO, Sanchez J, Zaidi SA, Bow E, Makarova M, Cao J, Shaik AB, Sulima A, Rice KC, Katritch V, Canals M, Lane JR, Newman AH. Bonifazi A, et al. Among authors: shaik ab. J Med Chem. 2021 Jun 10;64(11):7778-7808. doi: 10.1021/acs.jmedchem.1c00611. Epub 2021 May 20. J Med Chem. 2021. PMID: 34011153 Free PMC article.
A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder.
Galaj E, Bi GH, Klein B, Hempel B, Shaik AB, Gogarnoiu ES, Friedman J, Lam J, Rais R, Reed JF, Bloom SH, Swanson TL, Schmachtenberg JL, Eshleman AJ, Janowsky A, Xi ZX, Newman AH. Galaj E, et al. Among authors: shaik ab. Neuropsychopharmacology. 2022 Dec;47(13):2309-2318. doi: 10.1038/s41386-022-01379-1. Epub 2022 Jul 25. Neuropsychopharmacology. 2022. PMID: 35879349 Free PMC article.
Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders.
Gogarnoiu ES, Vogt CD, Sanchez J, Bonifazi A, Saab E, Shaik AB, Soler-Cedeño O, Bi GH, Klein B, Xi ZX, Lane JR, Newman AH. Gogarnoiu ES, et al. Among authors: shaik ab. J Med Chem. 2023 Feb 9;66(3):1809-1834. doi: 10.1021/acs.jmedchem.2c01624. Epub 2023 Jan 20. J Med Chem. 2023. PMID: 36661568 Free PMC article.
75 results