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A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2).
Geven C, Blet A, Kox M, Hartmann O, Scigalla P, Zimmermann J, Marx G, Laterre PF, Mebazaa A, Pickkers P. Geven C, et al. Among authors: hartmann o. BMJ Open. 2019 Feb 19;9(2):e024475. doi: 10.1136/bmjopen-2018-024475. BMJ Open. 2019. PMID: 30782906 Free PMC article.
Bioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study.
Lemasle L, Blet A, Geven C, Cherifa M, Deniau B, Hollinger A, Fournier MC, Monnet X, Rennuit I, Darmon M, Laterre PF, Struck J, Hartmann O, Bergmann A, Mebazaa A, Gayat E. Lemasle L, et al. Among authors: hartmann o. Crit Care Med. 2020 Jan;48(1):49-55. doi: 10.1097/CCM.0000000000004044. Crit Care Med. 2020. PMID: 31625979
High plasma dipeptidyl peptidase 3 levels are associated with mortality and organ failure in shock: results from the international, prospective and observational FROG-ICU cohort.
Deniau B, Picod A, Van Lier D, Vaittinada Ayar P, Santos K, Hartmann O, Gayat E, Mebazaa A, Blet A, Azibani F. Deniau B, et al. Among authors: hartmann o. Br J Anaesth. 2022 Feb;128(2):e54-e57. doi: 10.1016/j.bja.2021.11.021. Epub 2021 Dec 8. Br J Anaesth. 2022. PMID: 34895716 Free article. No abstract available.
Circulating dipeptidyl peptidase 3 is a myocardial depressant factor: dipeptidyl peptidase 3 inhibition rapidly and sustainably improves haemodynamics.
Deniau B, Rehfeld L, Santos K, Dienelt A, Azibani F, Sadoune M, Kounde PR, Samuel JL, Tolpannen H, Lassus J, Harjola VP, Vodovar N, Bergmann A, Hartmann O, Mebazaa A, Blet A. Deniau B, et al. Among authors: hartmann o. Eur J Heart Fail. 2020 Feb;22(2):290-299. doi: 10.1002/ejhf.1601. Epub 2019 Aug 31. Eur J Heart Fail. 2020. PMID: 31472040 Free article.
Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study.
Mebazaa A, Geven C, Hollinger A, Wittebole X, Chousterman BG, Blet A, Gayat E, Hartmann O, Scigalla P, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M, Laterre PF; AdrenOSS-1 study investigators. Mebazaa A, et al. Among authors: hartmann o. Crit Care. 2018 Dec 21;22(1):354. doi: 10.1186/s13054-018-2243-2. Crit Care. 2018. PMID: 30583748 Free PMC article.
Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study.
Blet A, Deniau B, Santos K, van Lier DPT, Azibani F, Wittebole X, Chousterman BG, Gayat E, Hartmann O, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M, Laterre PF, Mebazaa A; AdrenOSS-1 Study Investigators. Blet A, et al. Among authors: hartmann o. Crit Care. 2021 Feb 15;25(1):61. doi: 10.1186/s13054-021-03471-2. Crit Care. 2021. PMID: 33588925 Free PMC article.
428 results