Houghton M - Search Results

1

Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19.

Aminpour M, Delgado WEM, Wacker S, Noskov S, Houghton M, Tyrrell DLJ, Tuszynski JA. Aminpour M, et al. Among authors: houghton m. BMC Pharmacol Toxicol. 2021 Oct 21;22(1):61. doi: 10.1186/s40360-021-00519-5. BMC Pharmacol Toxicol. 2021. PMID: 34674775 Free PMC article.

2

A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity.

Anwar-Mohamed A, Barakat KH, Bhat R, Noskov SY, Tyrrell DL, Tuszynski JA, Houghton M. Anwar-Mohamed A, et al. Among authors: houghton m. Toxicol Lett. 2014 Nov 4;230(3):382-92. doi: 10.1016/j.toxlet.2014.08.007. Epub 2014 Aug 13. Toxicol Lett. 2014. PMID: 25127758

3

A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase.

Freedman H, Winter P, Tuszynski J, Tyrrell DL, Houghton M. Freedman H, et al. Among authors: houghton m. J Biol Chem. 2018 Jun 22;293(25):9696-9705. doi: 10.1074/jbc.RA118.002588. Epub 2018 May 8. J Biol Chem. 2018. PMID: 29739852 Free PMC article.

4

A Refined Model of the HCV NS5A protein bound to daclatasvir explains drug-resistant mutations and activity against divergent genotypes.

Barakat KH, Anwar-Mohamed A, Tuszynski JA, Robins MJ, Tyrrell DL, Houghton M. Barakat KH, et al. Among authors: houghton m. J Chem Inf Model. 2015 Feb 23;55(2):362-73. doi: 10.1021/ci400631n. Epub 2014 Apr 14. J Chem Inf Model. 2015. PMID: 24730573

5

Enhanced activation of memory, but not naïve, B cells in chronic hepatitis C virus-infected patients with cryoglobulinemia and advanced liver fibrosis.

Santer DM, Ma MM, Hockman D, Landi A, Tyrrell DL, Houghton M. Santer DM, et al. Among authors: houghton m. PLoS One. 2013 Jun 28;8(6):e68308. doi: 10.1371/journal.pone.0068308. Print 2013. PLoS One. 2013. PMID: 23840845 Free PMC article.

6

Detailed computational study of the active site of the hepatitis C viral RNA polymerase to aid novel drug design.

Barakat KH, Law J, Prunotto A, Magee WC, Evans DH, Tyrrell DL, Tuszynski J, Houghton M. Barakat KH, et al. Among authors: houghton m. J Chem Inf Model. 2013 Nov 25;53(11):3031-43. doi: 10.1021/ci4003969. Epub 2013 Oct 24. J Chem Inf Model. 2013. PMID: 24116674

7

Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome.

Landi A, Broadhurst D, Vernon SD, Tyrrell DL, Houghton M. Landi A, et al. Among authors: houghton m. Cytokine. 2016 Feb;78:27-36. doi: 10.1016/j.cyto.2015.11.018. Epub 2015 Nov 28. Cytokine. 2016. PMID: 26615570 Free article.

8

A computational model for overcoming drug resistance using selective dual-inhibitors for aurora kinase A and its T217D variant.

Barakat KH, Huzil JT, Jordan KE, Evangelinos C, Houghton M, Tuszynski J. Barakat KH, et al. Among authors: houghton m. Mol Pharm. 2013 Dec 2;10(12):4572-89. doi: 10.1021/mp4003893. Epub 2013 Nov 5. Mol Pharm. 2013. PMID: 24094068

9

Differential serum levels of eosinophilic eotaxins in primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis.

Landi A, Weismuller TJ, Lankisch TO, Santer DM, Tyrrell DL, Manns MP, Houghton M. Landi A, et al. Among authors: houghton m. J Interferon Cytokine Res. 2014 Mar;34(3):204-14. doi: 10.1089/jir.2013.0075. Epub 2013 Oct 29. J Interferon Cytokine Res. 2014. PMID: 24168449 Free PMC article.

10

A novel method for detection of IFN-lambda 3 binding to cells for quantifying IFN-lambda receptor expression.

Santer DM, Minty GES, Mohamed A, Baldwin L, Bhat R, Joyce M, Egli A, Tyrrell DLJ, Houghton M. Santer DM, et al. Among authors: houghton m. J Immunol Methods. 2017 Jun;445:15-22. doi: 10.1016/j.jim.2017.03.001. Epub 2017 Mar 6. J Immunol Methods. 2017. PMID: 28274837

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