Der CJ - Search Results

1

The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer.

Diehl JN, Klomp JE, Snare KR, Hibshman PS, Blake DR, Kaiser ZD, Gilbert TSK, Baldelli E, Pierobon M, Papke B, Yang R, Hodge RG, Rashid NU, Petricoin EF 3rd, Herring LE, Graves LM, Cox AD, Der CJ. Diehl JN, et al. Among authors: der cj. J Biol Chem. 2021 Nov;297(5):101335. doi: 10.1016/j.jbc.2021.101335. Epub 2021 Oct 22. J Biol Chem. 2021. PMID: 34688654 Free PMC article.

2

Ras (CXXX) and Rab (CC/CXC) prenylation signal sequences are unique and functionally distinct.

Khosravi-Far R, Clark GJ, Abe K, Cox AD, McLain T, Lutz RJ, Sinensky M, Der CJ. Khosravi-Far R, et al. Among authors: der cj. J Biol Chem. 1992 Dec 5;267(34):24363-8. J Biol Chem. 1992. PMID: 1332953 Free article.

3

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.

Cox AD, Hisaka MM, Buss JE, Der CJ. Cox AD, et al. Among authors: der cj. Mol Cell Biol. 1992 Jun;12(6):2606-15. doi: 10.1128/mcb.12.6.2606-2615.1992. Mol Cell Biol. 1992. PMID: 1375323 Free PMC article.

4

Protein prenylation: key to ras function and cancer intervention?

Khosravi-Far R, Cox AD, Kato K, Der CJ. Khosravi-Far R, et al. Among authors: der cj. Cell Growth Differ. 1992 Jul;3(7):461-9. Cell Growth Differ. 1992. PMID: 1419908 Review. No abstract available.

5

The ras/cholesterol connection: implications for ras oncogenicity.

Cox AD, Der CJ. Cox AD, et al. Among authors: der cj. Crit Rev Oncog. 1992;3(4):365-400. Crit Rev Oncog. 1992. PMID: 1420445 Review.

6

Protein prenylation: more than just glue?

Cox AD, Der CJ. Cox AD, et al. Among authors: der cj. Curr Opin Cell Biol. 1992 Dec;4(6):1008-16. doi: 10.1016/0955-0674(92)90133-w. Curr Opin Cell Biol. 1992. PMID: 1485954 Review.

7

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

Kato K, Cox AD, Hisaka MM, Graham SM, Buss JE, Der CJ. Kato K, et al. Among authors: der cj. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6403-7. doi: 10.1073/pnas.89.14.6403. Proc Natl Acad Sci U S A. 1992. PMID: 1631135 Free PMC article.

8

Isoprenoid modification and plasma membrane association: critical factors for ras oncogenicity.

Der CJ, Cox AD. Der CJ, et al. Cancer Cells. 1991 Sep;3(9):331-40. Cancer Cells. 1991. PMID: 1751286 Review.

9

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.

Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM. Lerner EC, et al. Among authors: der cj. J Biol Chem. 1995 Nov 10;270(45):26802-6. doi: 10.1074/jbc.270.45.26802. J Biol Chem. 1995. PMID: 7592920 Free article.

10

Two distinct Raf domains mediate interaction with Ras.

Brtva TR, Drugan JK, Ghosh S, Terrell RS, Campbell-Burk S, Bell RM, Der CJ. Brtva TR, et al. Among authors: der cj. J Biol Chem. 1995 Apr 28;270(17):9809-12. doi: 10.1074/jbc.270.17.9809. J Biol Chem. 1995. PMID: 7730360 Free article.

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