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Page 1
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.
Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. Huynh A, et al. Among authors: sage pt. Nat Immunol. 2015 Feb;16(2):188-96. doi: 10.1038/ni.3077. Epub 2015 Jan 5. Nat Immunol. 2015. PMID: 25559257 Free PMC article.
B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells.
Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. Zhang R, et al. Among authors: sage pt. J Immunol. 2017 Dec 15;199(12):3972-3980. doi: 10.4049/jimmunol.1700409. Epub 2017 Nov 1. J Immunol. 2017. PMID: 29093061 Free PMC article.
Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease.
Paz K, Flynn R, Du J, Qi J, Luznik L, Maillard I, MacDonald KP, Hill GR, Serody JS, Murphy WJ, Sage PT, Sharpe AH, Miklos D, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Bradner JE, Melnick AM, Blazar BR. Paz K, et al. Among authors: sage pt. Blood. 2019 Jan 3;133(1):94-99. doi: 10.1182/blood-2018-03-839993. Epub 2018 Oct 2. Blood. 2019. PMID: 30279226 Free PMC article.
Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease.
Paz K, Flynn R, Du J, Tannheimer S, Johnson AJ, Dong S, Stark AK, Okkenhaug K, Panoskaltsis-Mortari A, Sage PT, Sharpe AH, Luznik L, Ritz J, Soiffer RJ, Cutler CS, Koreth J, Antin JH, Miklos DB, MacDonald KP, Hill GR, Maillard I, Serody JS, Murphy WJ, Munn DH, Feser C, Zaiken M, Vanhaesebroeck B, Turka LA, Byrd JC, Blazar BR. Paz K, et al. Among authors: sage pt. Am J Transplant. 2019 Jun;19(6):1820-1830. doi: 10.1111/ajt.15305. Epub 2019 Mar 19. Am J Transplant. 2019. PMID: 30748099 Free PMC article.
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance.
Tan CL, Kuchroo JR, Sage PT, Liang D, Francisco LM, Buck J, Thaker YR, Zhang Q, McArdel SL, Juneja VR, Lee SJ, Lovitch SB, Lian C, Murphy GF, Blazar BR, Vignali DAA, Freeman GJ, Sharpe AH. Tan CL, et al. Among authors: sage pt. J Exp Med. 2021 Jan 4;218(1):e20182232. doi: 10.1084/jem.20182232. J Exp Med. 2021. PMID: 33045061 Free PMC article.
73 results