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Obesity risk is associated with altered cerebral glucose metabolism and decreased μ-opioid and CB1 receptor availability.
Kantonen T, Pekkarinen L, Karjalainen T, Bucci M, Kalliokoski K, Haaparanta-Solin M, Aarnio R, Dickens AM, von Eyken A, Laitinen K, Houttu N, Kirjavainen AK, Helin S, Hirvonen J, Rönnemaa T, Nuutila P, Nummenmaa L. Kantonen T, et al. Int J Obes (Lond). 2022 Feb;46(2):400-407. doi: 10.1038/s41366-021-00996-y. Epub 2021 Nov 2. Int J Obes (Lond). 2022. PMID: 34728775 Free PMC article.
Relationship between local perfusion and FFA uptake in human skeletal muscle-no effect of increased physical activity and aerobic fitness.
Hannukainen JC, Nuutila P, Kaprio J, Heinonen OJ, Kujala UM, Janatuinen T, Rönnemaa T, Kapanen J, Haaparanta-Solin M, Viljanen T, Knuuti J, Kalliokoski KK. Hannukainen JC, et al. J Appl Physiol (1985). 2006 Nov;101(5):1303-11. doi: 10.1152/japplphysiol.00012.2006. Epub 2006 Jul 6. J Appl Physiol (1985). 2006. PMID: 16825528 Free article.
Increased brain fatty acid uptake in metabolic syndrome.
Karmi A, Iozzo P, Viljanen A, Hirvonen J, Fielding BA, Virtanen K, Oikonen V, Kemppainen J, Viljanen T, Guiducci L, Haaparanta-Solin M, Någren K, Solin O, Nuutila P. Karmi A, et al. Diabetes. 2010 Sep;59(9):2171-7. doi: 10.2337/db09-0138. Epub 2010 Jun 21. Diabetes. 2010. PMID: 20566663 Free PMC article.
Pancreatic metabolism, blood flow, and β-cell function in obese humans.
Honka H, Hannukainen JC, Tarkia M, Karlsson H, Saunavaara V, Salminen P, Soinio M, Mikkola K, Kudomi N, Oikonen V, Haaparanta-Solin M, Roivainen A, Parkkola R, Iozzo P, Nuutila P. Honka H, et al. J Clin Endocrinol Metab. 2014 Jun;99(6):E981-90. doi: 10.1210/jc.2013-4369. Epub 2014 Feb 14. J Clin Endocrinol Metab. 2014. PMID: 24527718
Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome.
Bucci M, Karmi AC, Iozzo P, Fielding BA, Viljanen A, Badeau RM, Borra R, Saunavaara V, Pham T, Hannukainen JC, Kalliokoski K, Haaparanta-Solin M, Viljanen T, Parkkola R, Frayn KN, Nuutila P. Bucci M, et al. Diabetologia. 2015 Jan;58(1):158-64. doi: 10.1007/s00125-014-3402-x. Epub 2014 Oct 21. Diabetologia. 2015. PMID: 25331375 Clinical Trial.
The Cannabinoid Receptor-1 Is an Imaging Biomarker of Brown Adipose Tissue.
Eriksson O, Mikkola K, Espes D, Tuominen L, Virtanen K, Forsbäck S, Haaparanta-Solin M, Hietala J, Solin O, Nuutila P. Eriksson O, et al. J Nucl Med. 2015 Dec;56(12):1937-41. doi: 10.2967/jnumed.115.156422. Epub 2015 Sep 10. J Nucl Med. 2015. PMID: 26359260 Free article.
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