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SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance.
Jensen-Pergakes K, Tatlock J, Maegley KA, McAlpine IJ, McTigue M, Xie T, Dillon CP, Wang Y, Yamazaki S, Spiegel N, Shi M, Nemeth A, Miller N, Hendrickson E, Lam H, Sherrill J, Chung CY, McMillan EA, Bryant SK, Palde P, Braganza J, Brooun A, Deng YL, Goshtasbi V, Kephart SE, Kumpf RA, Liu W, Patman RL, Rui E, Scales S, Tran-Dube M, Wang F, Wythes M, Paul TA. Jensen-Pergakes K, et al. Among authors: patman rl. Mol Cancer Ther. 2022 Jan;21(1):3-15. doi: 10.1158/1535-7163.MCT-21-0620. Epub 2021 Nov 4. Mol Cancer Ther. 2022. PMID: 34737197
Copper-Catalyzed Chan-Lam Cyclopropylation of Phenols and Azaheterocycles.
Derosa J, O'Duill ML, Holcomb M, Boulous MN, Patman RL, Wang F, Tran-Dubé M, McAlpine I, Engle KM. Derosa J, et al. Among authors: patman rl. J Org Chem. 2018 Apr 6;83(7):3417-3425. doi: 10.1021/acs.joc.7b03100. Epub 2018 Mar 13. J Org Chem. 2018. PMID: 29498847 Free PMC article.
Cu-Catalyzed Hydroboration of Benzylidenecyclopropanes: Reaction Optimization, (Hetero)Aryl Scope, and Origins of Pathway Selectivity.
Medina JM, Kang T, Erbay TG, Shao H, Gallego GM, Yang S, Tran-Dubé M, Richardson PF, Derosa J, Helsel RT, Patman RL, Wang F, Ashcroft CP, Braganza JF, McAlpine I, Liu P, Engle KM. Medina JM, et al. Among authors: patman rl. ACS Catal. 2019 Dec 6;9(12):11130-11136. doi: 10.1021/acscatal.9b03557. Epub 2019 Oct 29. ACS Catal. 2019. PMID: 32617185 Free PMC article.
Discovery of Highly Selective Inhibitors of Microtubule-Associated Serine/Threonine Kinase-like (MASTL).
Gallego RA, Scales S, Toledo C, Auth M, Bernier L, Berry M, Brun S, Chung L, Davis C, Diehl W, Dress K, Eisele K, Elleraas J, Ewanicki J, Fobian Y, Greasley S, Greenwald EC, Johnson TW, Khamphavong P, Lafontaine J, Li J, Linton A, Maestre M, Miller N, Murtaza A, Patman RL, Quinlan CL, Ramms DJ, Richardson P, Sach N, Salomon-Ferrer R, Silva F, Timofeevski S, Tran P, Tran-Dubé M, Wang F, Wang W, Wythes M, Yang S, Zou A, VanArsdale T, McAlpine I. Gallego RA, et al. Among authors: patman rl. J Med Chem. 2024 Nov 14;67(21):19234-19246. doi: 10.1021/acs.jmedchem.4c01659. Epub 2024 Nov 5. J Med Chem. 2024. PMID: 39499084
18 results