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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
Sugiura A, Andrejeva G, Voss K, Heintzman DR, Xu X, Madden MZ, Ye X, Beier KL, Chowdhury NU, Wolf MM, Young AC, Greenwood DL, Sewell AE, Shahi SK, Freedman SN, Cameron AM, Foerch P, Bourne T, Garcia-Canaveras JC, Karijolich J, Newcomb DC, Mangalam AK, Rabinowitz JD, Rathmell JC. Sugiura A, et al. Among authors: xu x. Immunity. 2022 Jan 11;55(1):65-81.e9. doi: 10.1016/j.immuni.2021.10.011. Epub 2021 Nov 11. Immunity. 2022. PMID: 34767747 Free PMC article.
The Source of Glycolytic Intermediates in Mammalian Tissues.
TeSlaa T, Bartman CR, Jankowski CSR, Zhang Z, Xu X, Xing X, Wang L, Lu W, Hui S, Rabinowitz JD. TeSlaa T, et al. Among authors: xu x. Cell Metab. 2021 Feb 2;33(2):367-378.e5. doi: 10.1016/j.cmet.2020.12.020. Epub 2021 Jan 19. Cell Metab. 2021. PMID: 33472024 Free PMC article.
Methionine synthase supports tumour tetrahydrofolate pools.
Ghergurovich JM, Xu X, Wang JZ, Yang L, Ryseck RP, Wang L, Rabinowitz JD. Ghergurovich JM, et al. Among authors: xu x. Nat Metab. 2021 Nov;3(11):1512-1520. doi: 10.1038/s42255-021-00465-w. Epub 2021 Nov 18. Nat Metab. 2021. PMID: 34799699 Free PMC article.
Serine catabolism generates liver NADPH and supports hepatic lipogenesis.
Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz GJ, Clasquin MF, Rabinowitz JD. Zhang Z, et al. Among authors: xu x. Nat Metab. 2021 Dec;3(12):1608-1620. doi: 10.1038/s42255-021-00487-4. Epub 2021 Nov 29. Nat Metab. 2021. PMID: 34845393 Free PMC article.
Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth.
Zhao H, Teng D, Yang L, Xu X, Chen J, Jiang T, Feng AY, Zhang Y, Frederick DT, Gu L, Cai L, Asara JM, Pasca di Magliano M, Boland GM, Flaherty KT, Swanson KD, Liu D, Rabinowitz JD, Zheng B. Zhao H, et al. Among authors: xu x. Nat Metab. 2022 Dec;4(12):1660-1673. doi: 10.1038/s42255-022-00676-9. Epub 2022 Nov 14. Nat Metab. 2022. PMID: 36376563 Free PMC article.
Glycine homeostasis requires reverse SHMT flux.
McBride MJ, Hunter CJ, Zhang Z, TeSlaa T, Xu X, Ducker GS, Rabinowitz JD. McBride MJ, et al. Among authors: xu x. Cell Metab. 2024 Jan 2;36(1):103-115.e4. doi: 10.1016/j.cmet.2023.12.001. Cell Metab. 2024. PMID: 38171330
Selected Ion Monitoring for Orbitrap-Based Metabolomics.
Lu W, McBride MJ, Lee WD, Xing X, Xu X, Li X, Oschmann AM, Shen Y, Bartman C, Rabinowitz JD. Lu W, et al. Among authors: xu x. Metabolites. 2024 Mar 25;14(4):184. doi: 10.3390/metabo14040184. Metabolites. 2024. PMID: 38668312 Free PMC article.
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