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Structure, function and pharmacology of human itch GPCRs.
Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL. Cao C, et al. Among authors: chen h. Nature. 2021 Dec;600(7887):170-175. doi: 10.1038/s41586-021-04126-6. Epub 2021 Nov 17. Nature. 2021. PMID: 34789874 Free PMC article.
Light-induced control of protein destruction by opto-PROTAC.
Liu J, Chen H, Ma L, He Z, Wang D, Liu Y, Lin Q, Zhang T, Gray N, Kaniskan HÜ, Jin J, Wei W. Liu J, et al. Among authors: chen h. Sci Adv. 2020 Feb 21;6(8):eaay5154. doi: 10.1126/sciadv.aay5154. eCollection 2020 Feb. Sci Adv. 2020. PMID: 32128407 Free PMC article.
Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.
Shen Y, Li F, Szewczyk MM, Halabelian L, Park KS, Chau I, Dong A, Zeng H, Chen H, Meng F, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Liu J, Vedadi M, Jin J. Shen Y, et al. Among authors: chen h. J Med Chem. 2020 May 28;63(10):5477-5487. doi: 10.1021/acs.jmedchem.0c00406. Epub 2020 May 14. J Med Chem. 2020. PMID: 32367723 Free PMC article.
Cancer Selective Target Degradation by Folate-Caged PROTACs.
Liu J, Chen H, Liu Y, Shen Y, Meng F, Kaniskan HÜ, Jin J, Wei W. Liu J, et al. Among authors: chen h. J Am Chem Soc. 2021 May 19;143(19):7380-7387. doi: 10.1021/jacs.1c00451. Epub 2021 May 10. J Am Chem Soc. 2021. PMID: 33970635 Free PMC article.
TF-PROTACs Enable Targeted Degradation of Transcription Factors.
Liu J, Chen H, Kaniskan HÜ, Xie L, Chen X, Jin J, Wei W. Liu J, et al. Among authors: chen h, chen x. J Am Chem Soc. 2021 Jun 16;143(23):8902-8910. doi: 10.1021/jacs.1c03852. Epub 2021 Jun 8. J Am Chem Soc. 2021. PMID: 34100597 Free PMC article.
TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors.
Liu J, Yu X, Chen H, Kaniskan HÜ, Xie L, Chen X, Jin J, Wei W. Liu J, et al. Among authors: chen h, chen x. J Am Chem Soc. 2022 Jul 20;144(28):12934-12941. doi: 10.1021/jacs.2c04824. Epub 2022 Jul 5. J Am Chem Soc. 2022. PMID: 35786952 Free PMC article.
An MDM2 degrader for treatment of acute leukemias.
Marcellino BK, Yang X, Ümit Kaniskan H, Brady C, Chen H, Chen K, Qiu X, Clementelli C, Herschbein L, Li Z, Elghaity-Beckley S, Arandela J, Kelly B, Hoffman R, Liu J, Xiong Y, Jin J, Shih AH. Marcellino BK, et al. Among authors: chen k, chen h. Leukemia. 2023 Feb;37(2):370-378. doi: 10.1038/s41375-022-01735-6. Epub 2022 Oct 29. Leukemia. 2023. PMID: 36309559 Free PMC article.
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