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An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults.
Vieira VA, Adland E, Malone DFG, Martin MP, Groll A, Ansari MA, Garcia-Guerrero MC, Puertas MC, Muenchhoff M, Guash CF, Brander C, Martinez-Picado J, Bamford A, Tudor-Williams G, Ndung'u T, Walker BD, Ramsuran V, Frater J, Jooste P, Peppa D, Carrington M, Goulder PJR. Vieira VA, et al. Among authors: martin mp. PLoS Pathog. 2021 Nov 18;17(11):e1010090. doi: 10.1371/journal.ppat.1010090. eCollection 2021 Nov. PLoS Pathog. 2021. PMID: 34793581 Free PMC article.
HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
Carrington M, Nelson GW, Martin MP, Kissner T, Vlahov D, Goedert JJ, Kaslow R, Buchbinder S, Hoots K, O'Brien SJ. Carrington M, et al. Among authors: martin mp. Science. 1999 Mar 12;283(5408):1748-52. doi: 10.1126/science.283.5408.1748. Science. 1999. PMID: 10073943
344 results