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Concomitant variants in NF1, LZTR1 and GNAZ genes probably contribute to the aggressiveness of plexiform neurofibroma and warrant treatment with MEK inhibitor.
Cohen-Barak E, Toledano-Alhadef H, Danial-Farran N, Livneh I, Mwassi B, Hriesh M, Zagairy F, Gafni-Amsalem C, Bashir H, Khayat M, Warrour N, Sher O, Marom D, Postovsky S, Dujovny T, Ziv M, Shalev SA. Cohen-Barak E, et al. Among authors: mwassi b. Exp Dermatol. 2022 May;31(5):775-780. doi: 10.1111/exd.14514. Epub 2021 Dec 20. Exp Dermatol. 2022. PMID: 34913528