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Facile method to incorporate high-affinity ACAT/SOAT1 inhibitor F12511 into stealth liposome-based nanoparticle and demonstration of its efficacy in blocking cholesteryl ester biosynthesis without overt toxicity in neuronal cell culture.
De La Torre AL, Smith C, Granger J, Anderson FL, Harned TC, Havrda MC, Chang CCY, Chang TY. De La Torre AL, et al. J Neurosci Methods. 2022 Feb 1;367:109437. doi: 10.1016/j.jneumeth.2021.109437. Epub 2021 Dec 7. J Neurosci Methods. 2022. PMID: 34890698 Free PMC article.
Blocking cholesterol storage to treat Alzheimer's disease.
Chang TY, Chang CCY, Harned TC, De La Torre AL, Lee J, Huynh TN, Gow JG. Chang TY, et al. Among authors: de la torre al. Explor Neuroprotective Ther. 2021 Dec 30;1(3):173-184. doi: 10.37349/ent.2021.00014. Explor Neuroprotective Ther. 2021. PMID: 35199105 Free PMC article.
Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Transgenic Alzheimer's Disease Mice.
De La Torre AL, Huynh TN, Chang CCY, Pooler DB, Ness DB, Lewis LD, Pannem S, Feng Y, Samkoe KS, Hickey WF, Chang TY. De La Torre AL, et al. Int J Mol Sci. 2023 Jul 2;24(13):11013. doi: 10.3390/ijms241311013. Int J Mol Sci. 2023. PMID: 37446191 Free PMC article.
Prevalence and Etiology of Community-acquired Pneumonia in Immunocompromised Patients.
Di Pasquale MF, Sotgiu G, Gramegna A, Radovanovic D, Terraneo S, Reyes LF, Rupp J, González Del Castillo J, Blasi F, Aliberti S, Restrepo MI; GLIMP Investigators. Di Pasquale MF, et al. Clin Infect Dis. 2019 Apr 24;68(9):1482-1493. doi: 10.1093/cid/ciy723. Clin Infect Dis. 2019. PMID: 31222287 Free PMC article.