DeStefano JJ - Search Results

1

Physiological magnesium concentrations increase fidelity of diverse reverse transcriptases from HIV-1, HIV-2, and foamy virus, but not MuLV or AMV.

Wang R, Belew AT, Achuthan V, El Sayed N, DeStefano JJ. Wang R, et al. Among authors: destefano jj. J Gen Virol. 2021 Dec;102(12):001708. doi: 10.1099/jgv.0.001708. J Gen Virol. 2021. PMID: 34904939 Free PMC article.

2

Human immunodeficiency virus nucleocapsid protein stimulates strand transfer from internal regions of heteropolymeric RNA templates.

DeStefano JJ. DeStefano JJ. Arch Virol. 1995;140(10):1775-89. doi: 10.1007/BF01384341. Arch Virol. 1995. PMID: 7503678

3

Quantitative analysis of RNA cleavage during RNA-directed DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases.

DeStefano JJ, Mallaber LM, Fay PJ, Bambara RA. DeStefano JJ, et al. Nucleic Acids Res. 1994 Sep 11;22(18):3793-800. doi: 10.1093/nar/22.18.3793. Nucleic Acids Res. 1994. PMID: 7524028 Free PMC article.

4

Human immunodeficiency virus reverse transcriptase base misincorporations can promote strand transfer.

Diaz L, Cristofaro JV, DeStefano JJ. Diaz L, et al. Among authors: destefano jj. Arch Virol. 2000;145(6):1117-31. doi: 10.1007/s007050070113. Arch Virol. 2000. PMID: 10948986

5

In vitro strand transfer from broken RNAs results in mismatch but not frameshift mutations.

DeStefano JJ, Raja A, Cristofaro JV. DeStefano JJ, et al. Virology. 2000 Oct 10;276(1):7-15. doi: 10.1006/viro.2000.0533. Virology. 2000. PMID: 11021989 Free article.

6

Poliovirus protein 3AB displays nucleic acid chaperone and helix-destabilizing activities.

DeStefano JJ, Titilope O. DeStefano JJ, et al. J Virol. 2006 Feb;80(4):1662-71. doi: 10.1128/JVI.80.4.1662-1671.2006. J Virol. 2006. PMID: 16439523 Free PMC article.

7

A new role for HIV nucleocapsid protein in modulating the specificity of plus strand priming.

Jacob DT, DeStefano JJ. Jacob DT, et al. Among authors: destefano jj. Virology. 2008 Sep 1;378(2):385-96. doi: 10.1016/j.virol.2008.06.002. Epub 2008 Jul 15. Virology. 2008. PMID: 18632127 Free PMC article.

8

Viral reverse transcriptases show selective high affinity binding to DNA-DNA primer-templates that resemble the polypurine tract.

Nair GR, Dash C, Le Grice SF, DeStefano JJ. Nair GR, et al. Among authors: destefano jj. PLoS One. 2012;7(7):e41712. doi: 10.1371/journal.pone.0041712. Epub 2012 Jul 27. PLoS One. 2012. PMID: 22848574 Free PMC article.

9

Human immunodeficiency virus reverse transcriptase displays dramatically higher fidelity under physiological magnesium conditions in vitro.

Achuthan V, Keith BJ, Connolly BA, DeStefano JJ. Achuthan V, et al. Among authors: destefano jj. J Virol. 2014 Aug;88(15):8514-27. doi: 10.1128/JVI.00752-14. Epub 2014 May 21. J Virol. 2014. PMID: 24850729 Free PMC article.

10

Alternative divalent cations (Zn²⁺, Co²⁺, and Mn²⁺) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity.

Achuthan V, DeStefano JJ. Achuthan V, et al. Among authors: destefano jj. BMC Biochem. 2015 May 3;16:12. doi: 10.1186/s12858-015-0041-x. BMC Biochem. 2015. PMID: 25934642 Free PMC article.

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