Arruda AP - Search Results

1

Aberrant Ca²⁺ signaling by IP₃Rs in adipocytes links inflammation to metabolic dysregulation in obesity.

Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS. Guney E, et al. Among authors: arruda ap. Sci Signal. 2021 Dec 14;14(713):eabf2059. doi: 10.1126/scisignal.abf2059. Epub 2021 Dec 14. Sci Signal. 2021. PMID: 34905386 Free PMC article.

2

Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity.

Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamisligil GS. Arruda AP, et al. Nat Med. 2014 Dec;20(12):1427-35. doi: 10.1038/nm.3735. Epub 2014 Nov 24. Nat Med. 2014. PMID: 25419710 Free PMC article.

3

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.

Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K, Hotamisligil GS. Fu S, et al. Among authors: arruda ap. Sci Transl Med. 2015 Jun 17;7(292):292ra98. doi: 10.1126/scitranslmed.aaa9134. Sci Transl Med. 2015. PMID: 26084805 Free PMC article.

4

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes.

Arruda AP, Hotamisligil GS. Arruda AP, et al. Cell Metab. 2015 Sep 1;22(3):381-97. doi: 10.1016/j.cmet.2015.06.010. Epub 2015 Jul 16. Cell Metab. 2015. PMID: 26190652 Free PMC article. Review.

5

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.

Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS. Charles KN, et al. Among authors: arruda ap. Cell Rep. 2017 Oct 10;21(2):393-402. doi: 10.1016/j.celrep.2017.09.051. Cell Rep. 2017. PMID: 29020626 Free PMC article.

6

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS. Widenmaier SB, et al. Among authors: arruda ap. Cell. 2017 Nov 16;171(5):1094-1109.e15. doi: 10.1016/j.cell.2017.10.003. Cell. 2017. PMID: 29149604 Free article.

7

Defective STIM-mediated store operated Ca²⁺ entry in hepatocytes leads to metabolic dysfunction in obesity.

Arruda AP, Pers BM, Parlakgul G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS. Arruda AP, et al. Elife. 2017 Dec 15;6:e29968. doi: 10.7554/eLife.29968. Elife. 2017. PMID: 29243589 Free PMC article.

8

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Bartelt A, et al. Among authors: arruda ap. Nat Med. 2018 Mar;24(3):292-303. doi: 10.1038/nm.4481. Epub 2018 Feb 5. Nat Med. 2018. PMID: 29400713 Free PMC article.

9

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS. Tirosh A, et al. Among authors: arruda ap. Cell Metab. 2021 Feb 2;33(2):319-333.e6. doi: 10.1016/j.cmet.2020.11.009. Epub 2020 Dec 18. Cell Metab. 2021. PMID: 33340456 Free PMC article.

10

Regulation of liver subcellular architecture controls metabolic homeostasis.

Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamışlıgil GS. Parlakgül G, et al. Among authors: arruda ap. Nature. 2022 Mar;603(7902):736-742. doi: 10.1038/s41586-022-04488-5. Epub 2022 Mar 9. Nature. 2022. PMID: 35264794 Free PMC article.

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