Sharma AK - Search Results

1

Combinations of slow-translating codon clusters can increase mRNA half-life in Saccharomyces cerevisiae.

Sharma AK, Venezian J, Shiber A, Kramer G, Bukau B, O'Brien EP. Sharma AK, et al. Proc Natl Acad Sci U S A. 2021 Dec 21;118(51):e2026362118. doi: 10.1073/pnas.2026362118. Proc Natl Acad Sci U S A. 2021. PMID: 34911752 Free PMC article.

2

Quality control by a mobile molecular workshop: quality versus quantity.

Sharma AK, Chowdhury D. Sharma AK, et al. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Sep;82(3 Pt 1):031912. doi: 10.1103/PhysRevE.82.031912. Epub 2010 Sep 23. Phys Rev E Stat Nonlin Soft Matter Phys. 2010. PMID: 21230113

3

Stochastic theory of protein synthesis and polysome: ribosome profile on a single mRNA transcript.

Sharma AK, Chowdhury D. Sharma AK, et al. J Theor Biol. 2011 Nov 21;289:36-46. doi: 10.1016/j.jtbi.2011.08.023. Epub 2011 Aug 26. J Theor Biol. 2011. PMID: 21888920

4

Physical Origins of Codon Positions That Strongly Influence Cotranslational Folding: A Framework for Controlling Nascent-Protein Folding.

Sharma AK, Bukau B, O'Brien EP. Sharma AK, et al. J Am Chem Soc. 2016 Feb 3;138(4):1180-95. doi: 10.1021/jacs.5b08145. Epub 2016 Jan 21. J Am Chem Soc. 2016. PMID: 26716464

5

Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding.

Nissley DA, Sharma AK, Ahmed N, Friedrich UA, Kramer G, Bukau B, O'Brien EP. Nissley DA, et al. Among authors: sharma ak. Nat Commun. 2016 Feb 18;7:10341. doi: 10.1038/ncomms10341. Nat Commun. 2016. PMID: 26887592 Free PMC article.

6

Increasing Protein Production Rates Can Decrease the Rate at Which Functional Protein Is Produced and Their Steady-State Levels.

Sharma AK, O'Brien EP. Sharma AK, et al. J Phys Chem B. 2017 Jul 20;121(28):6775-6784. doi: 10.1021/acs.jpcb.7b01700. Epub 2017 Jul 7. J Phys Chem B. 2017. PMID: 28650169

7

Non-equilibrium coupling of protein structure and function to translation-elongation kinetics.

Sharma AK, O'Brien EP. Sharma AK, et al. Curr Opin Struct Biol. 2018 Apr;49:94-103. doi: 10.1016/j.sbi.2018.01.005. Epub 2018 Feb 3. Curr Opin Struct Biol. 2018. PMID: 29414517 Review.

8

Determinants of translation speed are randomly distributed across transcripts resulting in a universal scaling of protein synthesis times.

Sharma AK, Ahmed N, O'Brien EP. Sharma AK, et al. Phys Rev E. 2018 Feb;97(2-1):022409. doi: 10.1103/PhysRevE.97.022409. Phys Rev E. 2018. PMID: 29548178

9

Kinetic and structural comparison of a protein's cotranslational folding and refolding pathways.

Samelson AJ, Bolin E, Costello SM, Sharma AK, O'Brien EP, Marqusee S. Samelson AJ, et al. Among authors: sharma ak. Sci Adv. 2018 May 30;4(5):eaas9098. doi: 10.1126/sciadv.aas9098. eCollection 2018 May. Sci Adv. 2018. PMID: 29854950 Free PMC article.

10

A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data.

Sharma AK, Sormanni P, Ahmed N, Ciryam P, Friedrich UA, Kramer G, O'Brien EP. Sharma AK, et al. PLoS Comput Biol. 2019 May 23;15(5):e1007070. doi: 10.1371/journal.pcbi.1007070. eCollection 2019 May. PLoS Comput Biol. 2019. PMID: 31120880 Free PMC article.

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