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Synthon-based ligand discovery in virtual libraries of over 11 billion compounds.
Sadybekov AA, Sadybekov AV, Liu Y, Iliopoulos-Tsoutsouvas C, Huang XP, Pickett J, Houser B, Patel N, Tran NK, Tong F, Zvonok N, Jain MK, Savych O, Radchenko DS, Nikas SP, Petasis NA, Moroz YS, Roth BL, Makriyannis A, Katritch V. Sadybekov AA, et al. Among authors: zvonok n. Nature. 2022 Jan;601(7893):452-459. doi: 10.1038/s41586-021-04220-9. Epub 2021 Dec 15. Nature. 2022. PMID: 34912117 Free PMC article.
Oxa-adamantyl cannabinoids.
Ho TC, Tius MA, Nikas SP, Tran NK, Tong F, Zhou H, Zvonok N, Makriyannis A. Ho TC, et al. Among authors: zvonok n. Bioorg Med Chem Lett. 2021 Apr 15;38:127882. doi: 10.1016/j.bmcl.2021.127882. Epub 2021 Feb 24. Bioorg Med Chem Lett. 2021. PMID: 33636308
Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists.
Papanastasiou IP, Georgiadis MO, Iliopoulos-Tsoutsouvas C, Paronis CA, Brust CA, Tran NK, Ji L, Ma X, Wood JT, Zvonok N, Tong F, Bohn LM, Nikas SP, Makriyannis A. Papanastasiou IP, et al. Among authors: zvonok n. Eur J Med Chem. 2022 Feb 15;230:114027. doi: 10.1016/j.ejmech.2021.114027. Epub 2021 Dec 27. Eur J Med Chem. 2022. PMID: 35051750
Crystal Structure of the Human Cannabinoid Receptor CB2.
Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, Wang J, Wu M, Katritch V, Zhao S, Kunos G, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Li X, et al. Among authors: zvonok n. Cell. 2019 Jan 24;176(3):459-467.e13. doi: 10.1016/j.cell.2018.12.011. Epub 2019 Jan 10. Cell. 2019. PMID: 30639103 Free PMC article.
Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.
Alapafuja SO, Nikas SP, Bharathan IT, Shukla VG, Nasr ML, Bowman AL, Zvonok N, Li J, Shi X, Engen JR, Makriyannis A. Alapafuja SO, et al. Among authors: zvonok n. J Med Chem. 2012 Nov 26;55(22):10074-89. doi: 10.1021/jm301205j. Epub 2012 Nov 2. J Med Chem. 2012. PMID: 23083016 Free PMC article.
Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures.
Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ. Hua T, et al. Among authors: zvonok n. Cell. 2020 Feb 20;180(4):655-665.e18. doi: 10.1016/j.cell.2020.01.008. Epub 2020 Jan 30. Cell. 2020. PMID: 32004463 Free PMC article.
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