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Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates.
Østergaard ME, Jackson M, Low A, E Chappell A, G Lee R, Peralta RQ, Yu J, Kinberger GA, Dan A, Carty R, Tanowitz M, Anderson P, Kim TW, Fradkin L, Mullick AE, Murray S, Rigo F, Prakash TP, Bennett CF, Swayze EE, Gaus HJ, Seth PP. Østergaard ME, et al. Among authors: jackson m. Nucleic Acids Res. 2019 Jul 9;47(12):6045-6058. doi: 10.1093/nar/gkz360. Nucleic Acids Res. 2019. PMID: 31076766 Free PMC article.
Targeting alternative splicing of fibronectin in human renal proximal tubule epithelial cells with antisense oligonucleotides to reduce EDA+ fibronectin production and block an autocrine loop that drives renal fibrosis.
Phanish MK, Heidebrecht F, Jackson M, Rigo F, Dockrell MEC. Phanish MK, et al. Among authors: jackson m. Exp Cell Res. 2024 Sep 1;442(1):114186. doi: 10.1016/j.yexcr.2024.114186. Epub 2024 Aug 2. Exp Cell Res. 2024. PMID: 39098465 Free article.
5,172 results